General Information

Product

PREX2 Antibody Affinity Purified

Description

Affinity Purified PtdIns(3,4,5)-dependent Rac exchanger 2a Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 720-900 on PREX2 protein.

Accession #

GenBank:  DAA05334.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000-1:50,000

ELISA

1:20,000-1:50,000

Western Blot

1:500-1:750

Protein

Uniprot #

Q70Z35

Overview

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.

Molecular Function

Rac GTPase activator activity, Rac guanyl-nucleotide exchange factor activity

Expression

Isoform 1 is highly expressed in skeletal muscle, heart and placenta, absent from peripheral blood leukocytes. Isoform 2 is expressed in skeletal muscle, kidney, small intestine, and placenta. Isoform 3 is expressed in the heart.

Alternative Nomenclature

4 antibody

5)-dependent Rac exchanger 2 antibody

5-trisphosphate-dependent Rac exchanger 2 protein antibody

DEP domain-containing protein 2 antibody

DEP.2 antibody

Phosphatidylinositol 3 antibody

PtdIns(3,4,5)-dependent Rac exchanger 2 antibody

General Information

Product

Soluble Guanylyl Cyclase alpha 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 654-704 on rat Guanylyl cyclase alpha 1 subunit protein.

Accession #

GenBank: BAC24016.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8CJD2

Molecular Function

guanylate cyclase activity, heme binding, nucleotide binding

Alternative Nomenclature

GC S alpha 1 antibody

Guanylate cyclase soluble subunit alpha 1 antibody

Gucy1a1 antibody

Soluble guanylate cyclase large subunit antibody

General Information

Product

Soluble Guanylyl Cyclase alpha 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 680-730 on rat guanylate cyclase 1, soluble, alpha 2 protein.

Accession #

NCBI:  NP_076446.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:750

Protein

Uniprot #

Q9WVI4

Overview

Has guanylyl cyclase on binding to the beta-1 subunit.

Molecular Function

Lyase, GTP binding, heme binding

Subcellular Location

Cytoplasm

Structure

Heterodimer of an alpha and a  beta chain

Alternative Nomenclature

GC SA2 antibody

GCS alpha 2 antibody

Guanylate cyclase soluble subunit alpha-2 antibody

GUC1A2 antibody

GUCSA2 antibody

GUCY1A2 antibody

General Information

Product

Shibire Antibody

Description

Affinity Purified Shibire, isoform K Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Drosophila melanogaster (fruit fly)

Immunogen

Synthetic peptide taken within amino acid region 800-850 on D. melanogaster Shibire protein.

Accession #

NCBI:  NP_727910.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P27619

Overview

Microtubule-associated force-producing protein which is involved in the production of microtubule bundles and which is able to bind and hydrolyze GTP. Implicated in endocytic protein sorting.

Molecular Function

Hydrolase, Motor protein

Subcellular Location

Cytoplasm; Cytoskeleton

Structure

Contains 1 Dynamin-type G domain; Contains 1 GED domain; Contains 1 PH domain

Alternative Nomenclature

anon-WOO153538

CG18102

Ddyn

Ddyn3

Ddyn4

Shi

Shibere

General Information

Product

SYDE1 Antibody

Description

Affinity Purified Rho GTPase-activating protein SYDE1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

C. elegans, Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 680-735 on human SYDE1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.67-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q6ZW31

Overview

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

Molecular Function

Rho GTPase activator activity

Subcellular Location

Cerebellar mossy fiber, synaptic membrane, cytosol

Alternative Nomenclature

7h3 antibody

Protein syd 1 homolog 1 antibody

Rho GTPase activating protein SYDE1 antibody

SYDE1 antibody

Synapse defective protein 1 homolog 1 antibody

General Information

Product

ARHGEF7 Antibody

Description

Affinity Purified Rho-guanine nucleotide exchange factor 7 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 595-805 on human ARHGEF7 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q14155

Overview

Acts as RAC1 guanine nucleotide exchange factor and can induce membrane ruffling.

Molecular Function

Neurogenesis

Subcellular Location

Cell junction; foacl adhesion; Cell projection ruffle; Cell cortex

Structure

Interacts with PAK kinases through SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1.

Alternative Nomenclature

ARHG7 antibody

Beta pix antibody

COOL1 antibody

Nbla10314 antibody

P50 antibody

p85 antibody

P85SPR antibody

PAK interacting exchange factor beta antibody

PAK3 antibody

SH3 domain containing proline rich protein antibody

General Information

Product

EHD1 Antibody

Description

Affinity Purified EH domain-containing protein 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken wtihin amino acid region 515-565 on human EH-domain containing protein 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9H4M9

Overview

Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Plays a role in myoblast fusion. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth.

Molecular Function

Rab GTPase binding; ATP binding; calcium ion binding

Subcellular Location

Cell membrane, Endosome, Membrane

Expression

testis

Structure

Homooligomer, and heterooligomer with EHD2, EHD3 and EHD4, ATP-binding is required for heterooligomerization.

Alternative Nomenclature

CDABP0131 antibody

EH domain containing 1 antibody

FLJ42622 antibody

FLJ44618 antibody

H PAST antibody

PAST antibody

PAST1 antibody

Testilin antibody

General Information

Product

EHD4 Antibody

Description

Affinity Purified EH domain-containing protein 4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse Rat

Immunogen

Synthetic peptide taken within amino acid region 420-450 on EH-domain containing 4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9H223

Overview

Plays a role in early endosomal transport

Molecular Function

ATP binding;GTPase activity;nucleic acid binding;calcium ion binding;GTP binding

Subcellular Location

Cell membrane, Endosome, Membrane

Expression

Highly expressed in pancreas and heart.

Structure

Homooligomer, and heterooligomer with EHD1, EHD2 and EHD3

Alternative Nomenclature

EH domain containing 4 antibody

Hepatocellular carcinoma associated protein 10/11 antibody

HCA11 antibody

HGNC:3245 antibody

Ortholog of rat pincher antibody

PAST4 antibody

General Information

Product

Dexras1 Antibody

Description

Affinity Purified Dexamethasone-induced Ras-related protein 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Panda

Immunogen

Synthetic peptide:

HSDLMYIREKTSVGSQAKDKERC

corresponding to amino acids 256-278 of Mouse Dexras 1 protein.

Accession #

NCBI: NP_033052.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O35626

Overview

Small GTPase, negatively regulates the transcription regulation activity of the APBB1/FEF65-APP complex via its interaction with APBB1/FE65.

Molecular Function

GTP binding

Subcellular Location

Cell membrane, Lipid-anchor, Cytoplasmic side

Expression

Expressed in brain, heart, kidney and liver

Structure

Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP.  Interacts with APBB1/FE65.  Forms a ternary complex with CAPON and NOS1.

Alternative Nomenclature

Activator of G protein signaling 1 antibody

AGS1 antibody

Dexamethasone-induced Ras-related protein 1 antibody

Dexras 1 antibody

RAS dexamethasone induced 1 antibody

Ras related protein antibody

RASD 1 antibody

General Information

Product

SEPT1 Antibody Affinity Purified

Description

Affinity Purified Septin 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-350 on SEPT1 protein.

Accession #

Gen Bank: AAK61491.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.63-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8WYJ6

Overview

ilament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

Molecular Function

GTP binding

Subcellular Location

Cytoplasm, cytoskeleton, mictrotuble organizing center, centrosome; midbody. (Note: Remains at centrosomes and nearby microtubules throughout mitosis. Localizes to midbody during cytokinesis)

Expression

Expressed at high levels in lymphoid and hematopoietic tissues.

Alternative Nomenclature

DIFF6 antibody

Differentiation 6 (deoxyguanosine triphosphate triphosphohydrolase) antibody

LARP antibody

MGC20394 antibody

Peanut like protein 3 antibody

PNUTL3 antibody

SEP1 antibody

Serologically defined breast cancer antigen NY-BR-24 antibody