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Overview
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Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardio myocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAP, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implication the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaciton with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a rolei n the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). invovled in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be invovled in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin-and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. IS able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines produciton. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.
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alpha Actinin 4 Antibody FITC
alpha Actinin 4 Antibody BIOTIN
alpha Actinin 4 Blocking Peptide
alpha Actinin 4 Positive Control
Bovine Lactoferrin Antibody FITC
Bovine Lactoferrin Antibody BIOTIN
Bovine Lactoferrin Positive Control
Cofilin Antibody FITC
Cofilin Antibody BIOTIN
Cofilin Blocking Peptide
Cofilin Positive Control
MIG7 Antibody FITC
MIG7 Antibody BIOTIN
MIG7 Blocking Peptide
MIG7 Positive Control
SFRP2 Antibody FITC
SFRP2 Antibody BIOTIN
SFRP2 Blocking Peptide
SFRP2 Positive Control
Ephrin Receptor B2 Antibody FITC
Ephrin Receptor B2 Antibody BIOTIN
Ephrin Receptor B2 Blocking Peptide
Ephrin Receptor B2 Positive Control
Phospho-alpha Actinin 4 (S159) Antibody FITC
Phospho-alpha Actinin 4 (S159) Antibody BIOTIN
Phospho-alpha Actinin 4 Blocking Peptide
Phospho-alpha Actinin 4 Positive Control
PKC epsilon Antibody FITC
PKC epsilon Antibody BIOTIN
PKC epsilon Blocking Peptide
PKC epsilon Positive Control
CD99 Antibody FITC
CD99 Antibody BIOTIN
CD99 Blocking Peptide
CD99 Positive Control
CD99 Antibody FITC
CD99 Antibody BIOTIN
CD99 Blocking Peptide
