General Information |
|
Product |
GRK6 Antibody FITC |
Description |
FITC-Conjugated G protein-coupled receptor kinase 6 Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 500-550 on human G protein-coupled receptor kinase 6 protein. |
Accession # |
NCBI: NP_002073 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:50,000 |
Immunohistochemistry | 1:20-1:200 |
Immunoprecipitation |
1:200 |
Western Blot |
1:2,500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
Molecular Function |
ATP binding beta-adrenergic receptor kinase activity G-protein coupled receptor kinase activity |
Subcellular Location |
Membrane; Lipid-anchor |
Expression |
Widely expressed. |
Structure |
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. |
Alternative Nomenclature |
G protein coupled receptor kinase 6 antibody G protein coupled receptor kinase GRK6 antibody Gprk6 antibody Grk6 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
GRK6-601AP | |||
|
GRK6-BIOTIN | |||
|
P-GRK6 | |||
|
PC-GRK6 | |||
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