General Information
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Product
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5HT2A Receptor Positive Control
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Description
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Western Blot Positive Control 5-hydroxytryptamine receptor 2A Antibody
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Verified Applications
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WB
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Immunogen
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Purified protein.
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Accession #
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NCBI: NP_000612
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Physical Properties
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Quantity
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5 Applications
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Volume
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Inquire
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Form
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Western Blot Positive Control
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Storage
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-20⁰C for long term storage
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Application Protocol
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Western Blot
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1:500
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Protein
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Uniprot #
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P28223
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Overview
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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
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Molecular Function
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G-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer
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Subcellular Location
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Cell Membrane, Cell projection
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Expression
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Detected in brain cortex. Detected in blood platelets.
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Structure
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The PDZ domain-binding motif is involved in the interaction with PATJ, CASK, APBA1, DLG1 and DLG4.
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Alternative Nomenclature
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5 HT2 receptor antibody
5 HT2A antibody
5 hydroxytryptamine receptor 2A antibody
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled antibody
HTR 2A antibody
HTR2 antibody
serotonin 5-HT-2A receptor antibody
Serotonin receptor 2A antibody
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