General Information |
|
Product |
TREX1 Positive Control |
Description |
Western Blot Positive Control Three-prime repair exonuclease 1 Antibody |
Verified Applications |
WB |
Immunogen |
Purified Protein |
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|
Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:10,000 |
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Uniprot # |
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Overview |
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. |
Molecular Function |
Exonucleus, Hydrolase, Nuclease |
Subcellular Location |
Nucleus, Cytoplasm, Endoplasmic reticulum membrane; Peripheral membrane protein |
Expression |
Detected in thymus, spleen, liver, brain, heart, small intestine and colon. |
Structure |
Homodimer. Interacts (via proline-rich region) with TCERG1/CA150 (via the second WW domain). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Within this complex, directly interacts with SET; this interaction does not result in TREX1 inhibition. |
Alternative Nomenclature |
3' 5' exonuclease TREX1 antibody 3' repair exonuclease 1 antibody AGS1 antibody AGS5 antibody CRV antibody Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody DKFZp434J0310 antibody DNase III antibody DRN3 antibody HERNS antibody Three prime repair exonuclease 1 antibody TREX1 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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TREX1-101AP | |||
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TREX1-FITC | |||
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P-TREX1 | |||
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TREX1-BIOTIN | |||
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