General Information |
|
Product |
Integrin beta 3 Antibody FITC-Conjugated |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Monkey |
Immunogen |
Synthetic peptide taken within amino acid region 1-50 on human Integrin Beta 3 subunit protein. |
Accession # |
GenBank: AAB23689.2 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.55-0.75 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:150 |
Immunohistochemistry | 1:100 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
Molecular Function |
Cell adhesion, Host-virus interaction |
Subcellular Location |
Cell junction, Cell membrane, Cell projection, Membrane |
Expression |
Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis. |
Structure |
Heterodimer of an alpha and a beta subunit. Beta-3 (ITGB3) associates with either alpha-IIb (ITGA2B) or alpha-V (ITGAV). Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10. Interacts with DAB3. Interacts with FERMT2. Interacts with EMP2; regulates the levels of the heterodimer ITGA5:ITGB3 integrin expression on the plasma membrane (PubMed:16216233). Integrin ITGAV:ITGB3 interacts with FBLN5 (via N-terminus). Integrin ITGAV:ITGB3 interacts with herpes virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus. Interacts with HIV-1 Tat. |
Alternative Nomenclature |
BDPLT16 antibody BDPLT2 antibody CD61 antibody GP3A antibody GT antibody HPA 1 antibody HPA 4 antibody Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody Integrin beta chain beta 3 antibody ITGB 3 antibody NAIT antibody Platelet fibrinogen receptor, beta subunit antibody Platelet glycoprotein IIIa antibody Platelet membrane glycoprotein IIIa antibody PTP antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
INTGB3-101AP | |||
|
P-INTGB3 | |||
|
INTGB3-BIOTIN | |||
|
PC-INTGB3 | |||
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