General Information |
|
Product |
TREX1 Peptide |
Description |
Antigenic Blocking Peptide Three-prime repair exonuclease 1 Antibody |
Verified Applications |
Immunocompeition, Immunodepletion |
Peptide Description |
Synthetic peptide taken within amino acid region 220-245 on human TREX1 protein. |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
|
|
|
Uniprot # |
|
Overview |
Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. |
Molecular Function |
Exonucleus, Hydrolase, Nuclease |
Subcellular Location |
Nucleus, Cytoplasm, Endoplasmic reticulum membrane; Peripheral membrane protein |
Expression |
Detected in thymus, spleen, liver, brain, heart, small intestine and colon. |
Structure |
Homodimer. Interacts (via proline-rich region) with TCERG1/CA150 (via the second WW domain). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. |
Alternative Nomenclature |
3' 5' exonuclease TREX1 antibody 3' repair exonuclease 1 antibody AGS1 antibody AGS5 antibody CRV antibody Deoxyribonuclease III, dnaQ/mutD (E. coli) like antibody DKFZp434J0310 antibody DNase III antibody DRN3 antibody HERNS antibody Three prime repair exonuclease 1 antibody TREX1 antibody |
Protein information supplied byUniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
TREX1-101AP | |||
|
TREX1-FITC | |||
|
TREX1-BIOTIN | |||
|
PC-TREX1 | |||
Display accessory details |
Select your currency:
(c) FabGennix International Inc.