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General Information
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Product
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ASIC2 Antibody
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Description
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Affinity Purified Acid-sensing ion channel 2 Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 450-512 on human Acid-sensing ion channel 2 protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunoprecipitation
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1:200
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Western Blot
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1:2,500-1:5,000
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Protein
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Uniprot #
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Q16515
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Overview
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Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li+ and K+. Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
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Molecular Function
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acid-sensing ion channel activity; ion gated channel activity; ligand-gated sodium channel activity
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Subcellular Location
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Cell membrane; Multi-pass membrane protein
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Expression
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Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
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Structure
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Homotrimer or heterotrimer with other ASIC proteins.
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Alternative Nomenclature
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ACCN1 antibody
Acid sensing ion channel 2 antibody
Amiloride sensitive brain sodium channel antibody
Amiloride sensitive cation channel 1 neuronal antibody
ASIC2 antibody
BNaC1 antibody
Brain sodium channel 1 antibody
Degenerin antibody
Mammalian degenerin homolog antibody
MDEG antibody
Neuronal amiloride sensitive cation channel 1 antibody
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ASIC2 Antibody BIOTIN
ASIC2 Antibody FITC
ASIC2 Blocking Peptide
ASIC2 Positive Control
