General Information
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Product
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PDE1C Antibody
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Description
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Affinity Purified Pan Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A) Antibody C-epitope
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Verified Applications
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CM, ELISA, ICC, IF, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene. The sequence was taken within amino acid region 10-70.
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Specificity |
This antibody does not cross-react with PDE1A, PDE1B, or other PDE family members. This antibody will label all PDE1C variants including PDE1C1, PDE1C2, and PDE1C3. |
Accession #
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GenBank: U40371.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Determinant
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This antibody is labeled as C-epitope, because it was taken closer to the C-terminus in relation to our other PDE1C antibody (PD1C-301AP).
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Storage
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-20⁰C for long term storage
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Application Protocol
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Confocal Microscopy
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1:40-1:100
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DB
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1:10,000
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ELISA
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1:10,000
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Immunocytochemistry
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1:40-1:100
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Immunofluorescence
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1:200
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Immunohistochemistry
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1:40-1:100
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Immunoprecipitation
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1:200
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Western Blot
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1:500-1:2,000
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Protein
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Uniprot #
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Q14123
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Overview
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Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.
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Molecular Function
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Hydrolase, calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, metal ion binding
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Subcellular Location
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Cytosol
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Expression
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Expressed in several tissues, including brain and heart.
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Structure
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Homodimer
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Alternative Nomenclature
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5''-cyclic nucleotide phosphodiesterase 1C antibody
Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C antibody
Cam PDE 1C antibody
HCAM3 antibody
HSPDE1C1A antibody
Human 3'5' cyclic nucleotide Phosphodiesterase antibody
PDE 1C antibody
Phosphodiesterase 1C antibody
Phosphodiesterase 1C calmodulin dependent antibody
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