General Information
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Product
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Syncytin A Antibody BIOTIN
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Description
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BIOTIN-Conjugated Envelope glycoprotein syncytin-A Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 180-230 on rat Envelope glycoprotein syncytin-A protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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BIOTIN-Conjugated
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunohistochemistry |
1:50-1:100 |
Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q5G5D4
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Overview
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This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904).3 Publications
Endogenous envelope proteins may have kept, lost or modified their original function during evolution.
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Molecular Function
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Anatomical structure morphogenesis, syncytium formation
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Subcellular Location
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Cell membrane
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Expression
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Expressed at higher level in placental syncytiotrophoblast. Expressed at intermediate level in testis. Seems also to be found at low level in adrenal tissue, bone marrow, breast, colon, kidney, ovary, prostate, skin, spleen, thymus, thyroid, brain and trachea. Both mRNA and protein levels are significantly increased in the brain of individuals with multiple sclerosis, particularly in astrocytes and microglia.
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Structure
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The cytoplasmic region is essential for the fusiogenic function.
The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.
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Alternative Nomenclature
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Endogenous retrovirus group W member 1 antibody
env antibody
Env-W antibody
Envelope polyprotein gPr73 antibody
Enverin antibody
ERVW antibody
ERVW-1 antibody
Gp24 antibody
Gp50 antibody
HERV-7q Envelope protein antibody
HERV-W envelope protein antibody
HERVW antibody
SU antibody
Syncytin A antibody
TM antibody
Transmembrane protein antibody
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