General Information |
|
Product |
D6 Peptide |
Description |
Antigenic Blocking Peptide Atypical chemokine receptor 2 |
Verified Applications |
Immmunodepletion, Competition Assay |
Peptide Description |
Synthetic peptide taken within amino acid region 300-378 mouse Atypical chemokine receptor 2 protein. |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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|
Competition/Depletion assay |
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Uniprot # |
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Overview |
Controls chemokine levels and localization via high-affinity chemoking binding that is uncoupled from classic liand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells and is required for immature/mature dendritic cells discrimination. |
Molecular Function |
Chemokine Receptor activity; Scavenger receptor activity |
Subcellular Location |
Early endosome; Recycling endosome; Cell membrane; Multi-pass membrane protein |
Expression |
Endothelial cells lining afferent lympatics in dermis and lymph nodes. Also found n subcapsular and medullary sinuses, tonsillar lympatic sinuses and lymphatics in mucosa and submucosa of appendix, small intestine, and large intestine. Experssed in Kapo |
Structure |
C-terminal cytoplasmic tail controls phosphorylation, stability, intracellular trafficking and chemokine scavenging properties. |
Alternative Nomenclature |
ACKR2 antibody Atypical chemokine receptor 2 antibody Chemokine binding protein 2 antibody Chemokine receptor CCR 10 antibody Chemokine receptor CCR 9 antibody CMKBR9 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
ACRD6-612AP | |||
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ACRD6M-FITC | |||
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ACRD6M-BIOTIN | |||
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PC-ACRD6 | |||
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