General Information
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Product
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CARD15 Peptide
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Description
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Antigenic Blocking Peptide Nucleotide-binding oligomerization domain-containing protein 2
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Verified Applications
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Immunodepletion, Immunocompetition
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Immunogen
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Synthetic peptide taken within amino acid region 700-780 on mouse Nucleotide-binding oligomerization domain-containing protein 2.
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Accession #
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Gen Bank: AAH44774
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q8K3Z0
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Overview
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Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response (PubMed:22607974). Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).
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Molecular Function
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actin binding
ATP binding
CARD domain binding
endodeoxyribonuclease activity, producing 5'-phosphomonoesters
enzyme binding
Hsp70 protein binding
Hsp90 protein binding
muramyl dipeptide binding
peptidoglycan binding
protein kinase binding
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Subcellular Location
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Cytoplasm
Membrane
Basolateral cell membrane
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Structure
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The ATG16L1-binding motif mediates interaction with ATG16L1.
Intramolecular interactions between the N-terminal moiety and the leucine-rich repeats (LRR) may be important for autoinhibition in the absence of activating signal. In the absence of LRRs, the protein becomes a constitutive activator of CASP1 cleavage and proIL1B processing.
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Alternative Nomenclature
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ACUG antibody
Arthrocutaneouveal granulomatosis antibody
BLAU antibody
CARD15 antibody
Caspase recruitment domain protein 15 antibody
CD antibody
CLR16.3 antibody
IBD1 antibody
Inflammatory bowel disease protein 1 antibody
LRR containing protein antibody
NLR family, CARD domain containing 2 antibody
NLRC2 antibody
NOD like receptor C2 antibody
NOD2 antibody
NOD2B antibody
Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2 antibody
PSORAS1 antibody
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