BACE2 A/C Antibody

Product no.: BACE-201AP
$295.00
$265.00


General Information

 

 

Product

 

BACE2 A/C Antibody

Description

Affinity Purified Beta Secretase beta-site APP cleaving Enzyme 2A/C Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Predicted: Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 490-518 on human BACE2 protein.

Specificity This antibody will only detect BACE2A and BACE2C protein.

Accession #

GenBank: AAQ89286


Physical Properties

 

 

Quantity

 

100 µg

Volume

200 µl

Concentration

0.72-0.76 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20C for long term storage


Application Protocol

 

DB

1:10,000

ELISA

1:10,000

Immunohistochemistry 1:50-1:150
Immunoprecipitation 1:200

Western Blot

1:500


Protein

 

 

Uniprot #

 

Q9Y5Z0

Overview

Responsible for the proteolytic processing of the amyloid precursor protein. Cleaves APP between 690 and 691 leading to the generation and extracellular release of beta-cleaved soluble APP and C-terminal fragment which is later released by gamma-secretase.

Molecular Function

Aspartic-type endopeptidase activity.

Subcellular Location

Endoplasmic reticulum, Endosome, Golgi apparatus; Membrane

Expression

Neurons within the hippocampus, frontal cortex and temporal cortex. Lower expression in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Also found in spinal cord, medulla oblongata, substania nigra and locus coruleus. Expressed in ductal epithelium of prostate.

Structure

Belongs to the peptidase A1 family.

Alternative Nomenclature

ALP 56 antibody

ASP1 antibody

ASP21 antibody

Aspartic Like Protease 56kDa antibody

Downs Syndrome Region Aspartic Protease antibody

DRAP antibody

Memapsin-1 antibody

Membrane associated aspartic protease 1 antibody

Theta-secretase antibody

Protein information supplied by UniProt
 

 

Accessories

Product Note Status Price
BACE2 A/C Antibody FITC BACE2 A/C Antibody FITC
BACE2-FITC $350.00 *
BACE2 A/C Antibody BIOTIN BACE2 A/C Antibody BIOTIN
BACE2-BIOTIN $350.00 *
BACE2 A/C Blocking Peptide BACE2 A/C Blocking Peptide
P-BACE2 $145.00 *
BACE2 A/C Positive Control BACE2 A/C Positive Control
PC-BACE2 $185.00 *
Display accessory details

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