General Information |
|
Product |
IKAP Peptide |
Description |
Antigenic Blocking Peptide Elongator complex protein 1 Antibody |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 1280-1330 on mouse Elongator Complex Protein 1. |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
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|
|
Uniprot # |
|
Overview |
May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Involved in neurogenesis (PubMed:19185337). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). |
Molecular Function |
Phosphorylase kinase regulator activity |
Subcellular Location |
Cytoplasm, Nucleus |
Expression |
Widely expressed with highest levels in brain. |
Alternative Nomenclature |
DYS antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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IKAP-112AP | |||
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IKAP-112-BIOTIN | |||
|
IKAP-112-FITC | |||
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PC-IKAP | |||
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