General Information
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Product
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IKAP Peptide
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Description
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Antigenic Blocking Peptide Elongator complex protein 1 Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide taken within amino acid region 1280-1330 on mouse Elongator Complex Protein 1.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q7TT37
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Overview
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May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Involved in neurogenesis (PubMed:19185337). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337).
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Molecular Function
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Phosphorylase kinase regulator activity
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Subcellular Location
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Cytoplasm, Nucleus
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Expression
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Widely expressed with highest levels in brain.
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Alternative Nomenclature
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DYS antibody
Dysautonomia (Riley Day syndrome hereditary sensory autonomic neuropathy type III) antibody
Elongator complex protein 1 antibody
ELP1 antibody
FD antibody
IKAP antibody
IkappaB kinase complex associated protein antibody
ikbkap antibody
IKI3 antibody
IKK complex associated protein antibody
Inhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein antibody
p150 antibody
TOT1 antibody
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