General Information

Product

Septin 2 Antibody Affinity Purified

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 270-320 on human Septin-2 protein.

Accession #

Gen Bank:  AAH14455.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q15019

Overview

Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating effiecient vesicle transport, and by impeding MAP4 binding to tubulin. Required for progression through mitosis.

Molecular Function

Enzyme regulator activity

Subcellular Location

Cytoplasm, cytoskeleton, spindle, cleavage furrow, midbody, cell cortex, cilium membrane

Expression

Widely expressed. Up-regulated in liver cancer.

Alternative Nomenclature

DIFF6 antibody

KIAA0158 antibody

NEDD 5 antibody

Neural precursor cell expressed developmentally down regulated protein 5 antibody

Pnutl3 antibody

Protein NEDD5 antibody

septin 2 antibody

General Information

Product

Septin 3 Antibody Affinity Purified

Description

Affinity Purified Septin 3 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 260-330 on SEPT3 protein.

Accession #

Gen Bank:  CAQ07552.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9UH03

Overview

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

Molecular Function

GTP binding

Subcellular Location

Cytoplasm, cell junction

Expression

Brain-specific

Alternative Nomenclature

bK250D10.3 antibody

MGC133218 antibody

Neuronal specific septin 3 antibody

SEP3 antibody

SEPT 3 antibody

Septin3 antibody

General Information

Product

ARTS Antibody Affinity Purified

Description

Affinity Purified Septin-4 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-450 on SEPT4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-075 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O43236

Overview

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli.

Molecular Function

GTPase activity, structural molecule activity, GTP binding

Subcellular Location

Cytoplasm, cytoskeleton. (Note: In platelets, found in areas surrounding alpha-granules)

Expression

Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in plate

Alternative Nomenclature

Apoptosis Related Protein TGFb Signalling antibody

ARTS antibody

Bradeion beta antibody

Brain protein H5 antibody

CE5B3 antibody

CE5B3 beta antibody

cell division control-related protein 2 antibody

cerebral protein 7 antibody

H5 antibody

hCDCREL-2 antibody

Hucep 7 antibody

MART antibody

Peanut-like protein 2 antibody

PNUTL2 antibody

SEP4 antibody

SEPT4 antibody

Septin-4 antibody

General Information

Product

SEPT5 Antibody

Description

Affinity Purified Septin-5 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-350 on SEPT5 protein.

Accession #

NCBI:  NP_002679.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q99719

Overview

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion.

Molecular Function

GTPase activity, structural molecule activity, GTP binding

Subcellular Location

Cytoplasm, cytoskeleton. (Note: In platelets, found in areas surrounding alpha-granules)

Expression

Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).

Alternative Nomenclature

5 Sep antibody

CDCREL1 antibody

Cell division control related protein 1 antibody

H5 antibody

HCDCREL 1 antibody

Peanut like 1 homolog antibody

Peanut-like protein 1 antibody

Platelet glycoprotein Ib beta chain antibody

PNUTL1 antibody

SEPT5 antibody

Septin 5 antibody

General Information

Product

SEPT6 Antibody Affinity Purified

Description

Affinity Purified Septin 6 Mrna Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 370-430 on SEPT6 protein.

Accession #

Gen Bank: AF397023.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.54-0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q548C9

Molecular Function

GTP binding

Subcellular Location

Septin complex

Structure

Belongs to Septin Family, Contains septin-type G (guanine nucleotide-binding) domain.

Alternative Nomenclature

KIAA0128 antibody

Nkrf antibody

RCG53214, isoform CRA_d antibody

RP5-876A24.2 antibody

SEP2 antibody

SEPT2 antibody

SEPT6/MLL FUSION GENE antibody

Septin 2 antibody

Septin 6 antibody

General Information

Product

SEPT7 Antibody Affinity Purified

Description

Affinity Purified Septin 7 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 350-430 on SEPT7 protein.

Accession #

Gen Bank: ABB17294.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8TC62

Molecular Function

GTP binding

Subcellular Location

Septin complex

Structure

Belongs to Septin Family, Contains septin-type G (guanine nucleotide-binding) domain.

Alternative Nomenclature

CDC10 antibody

CDC10 cell division cycle 10 homolog antibody

CDC10 protein homolog antibody

CDC3 antibody

Cell division cycle 10 antibody

E430034N22 antibody

KIAA4020 antibody

Nbla02942 antibody

SEPT7A antibody

General Information

Product

Septin 8 Antibody Affinity Purified

Description

Affinity Purified Septin-8 isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on SEPT8 protein.

Accession #

NCBI:  NP_149156.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8CHH9

Overview

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity).

Molecular Function

GTP binding

Subcellular Location

Cytoplasm, cytoskeleton

Structure

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with CDK14, SEPT4, S

Alternative Nomenclature

KIAA0202 antibody

OTTHUMP00000211755 antibody

SEP2 antibody

SEPT8 antibody

Septin8 antibody

General Information

Product

MSF Antibody

Description

Affinity Purified Septin 9 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-60 on SEPT9 protein.

Accession #

Gen Bank:  AAH21192.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.69 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9UHD8

Overview

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

Molecular Function

GTPase activity

Subcellular Location

Cytoplasm, cytoskeleton.

Expression

Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity.

Alternative Nomenclature

Cell division control protein septin D1 antibody

MLL septin-like fusion protein MSF-A antibody

MSF1 antibody

NAPB antibody

Ov/Br septin antibody

Ovarian/breast septin alpha antibody

PNUTL4 antibody

SeptD1 antibody

Septin 9 antibody

Septin D1 antibody

SINT1 antibody

General Information

Product

RASGRF2 Antibody

Description

Affinity Purified Ras-specific guanine nucleotide-releasing factor 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Immunogen

Synthetic peptide taken within amino acid region 1100-1200 on human RASGRF2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O14827

Overview

Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP.  Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation.

Molecular Function

Guanine-nucleotide releasing factor, Rho guayl-nucleotide exchange factor activity

Subcellular Location

Cytoplasm, Cell membrane; Peripheral membrane protein, Endoplasmic reticulum membrane; Peripheral membrane protein

Expression

Widely expressed with higher expression in the brain, followed by heart, lung, pancreas and kidney.  Detected in placenta.  Expressed in brain and lung.

Structure

Homooligomer and heterooligomer with RASGRF1.  Interacts with Ras and RAC1.  Interacts in a calcium-dependent manner with calmodulin.

Alternative Nomenclature

GRF2 antibody

Ras guanine nucleotide exchange factor 2 antibody

Ras-GRF2 antibody

General Information

Product

RASD2 Antibody

Description

Affinity Purified Ras homolog enriched in striatum Antibody

Verified Applications

ELISA, IHC ,IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 250-317 on RASD2 protein.

Accession #

GenBank: AAH36988.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:500

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q8JZW1

Molecular Function

GTP binding

Alternative Nomenclature

GTP binding protein Rhes antibody

MGC:4834 antibody

Ras homolog enriched in striatum antibody

RASD 2 antibody

Rhes antibody

TEM2 antibody

Tumor endothelial marker 2 antibody