Dopamine D2 Receptor Antibody

General Information

Product

Dopamine D2 Receptor Antibody 

Description

Dopamine Receptor subtype D2 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 on rat Dopamine Receptor D2 protein.

Accession #

GenBank: AAA41075.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

ELISA

1:50,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:1,000-1:1,5000

Protein

Uniprot #

Q6LDH7

Overview

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

Molecular Function

Dopamine Binding; Potassium Channel Regulator activity; Identical Protein binding

Subcellular Location

Cell membrane; Multi-pass membrane protein

Structure

Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2. Interacts with ARRB2 (By similarity). Interacts with KCNA2 (By similarity). Interacts with GNAI1 (PubMed:17264214). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Interacts with HTR2A.

Alternative Nomenclature

D(2) dopamine receptor antibody

D2 dopamine receptor antibody

D2DR antibody

D2R antibody

Dopamine D2 receptor antibody

DRD2 antibody