General Information
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Product
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EDG8 Antibody FITC-Conjugated
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Description
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FITC-Conjugated Sphingosine 1-phosphate receptor 5 Antibody
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Verified Applications
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ELISA, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 380-400 of rat S1P5R/EDG8 protein.
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Does not cross eact to other Spingosine 1-phosphate receptor subtypes. Labels a strong band of EDG8 of 48-50 kDa. Also labels a 54 kDa band, the identity of this is not known but may represent phosphorylated EDG8. |
Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.52-0.63 µg/µl in antibody stabilization buffer
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Form
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FITC-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Western Blot
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1:500
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Protein
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Uniprot #
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Q9JKM5
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Overview
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Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/O)alpha and G(12) subclass of heteromeric G-proteins.
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Molecular Function
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G-protein coupled receptor, Receptor, Transducer
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Subcellular Location
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Cell membrane; Multi-pass membrane protein
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Expression
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Found almost exclusively in brain and skin. Ubiquitously detected in different brain regions with very prominent expression in lower brain regions such as the midbrain, pons, medulla, and spinal cord. Expressed predominantly within white matter tracts of
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Alternative Nomenclature
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EDG 8 antibody
Endothelial differentiation G protein coupled receptor 8 antibody
Endothelial differentiation sphingolipid G protein coupled receptor 8 antibody
S1P receptor 5 antibody
S1P receptor Edg 8 antibody
Sphingosine 1 Phosphate Receptor 5 antibody
Sphingosine 1-phosphate receptor Edg-8 antibody
SPPR2 antibody
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