General Information |
|
Product |
Phospho PDE4D ERK site Antibody BIOTIN |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Phosphorylated synthetic peptide selective for PDE4D ERK site taken within amino acid ergion 550-600 on human PDE4D8 protein. |
Accession # |
NCBI: NP_001184148.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.57 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Determinant |
|
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Apical cell membrane, Cytoplasm, Membrane |
Expression |
Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. |
Structure |
Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). |
Alternative Nomenclature |
cAMP specific 3',5' cyclic phosphodiesterase 4D antibody DKFZp686M11213 antibody 5''-cyclic phosphodiesterase 4D antibody cAMP specific 3' 5' cyclic phosphodiesterase 4D antibody cAMP specific phosphodiesterase 4D antibody cAMP specific phosphodiesterase PDE4D antibody cAMP specific phosphodiesterase PDE4D6 antibody cAMP-specific 3'' antibody cyclic AMP phosphodiesterase antibody DPDE3 antibody Dunce like phosphodiesterase E3 antibody FLJ97311 antibody HSPDE4D antibody PDE43 antibody PDE4DN2 antibody Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3) antibody Phosphodiesterase 4D cAMP specific (phosphodiesterase E3 dunce homolog Drosophila) antibody Phosphodiesterase 4D cAMP specific antibody Phosphodiesterase E3 dunce homolog Drosophila antibody STRK 1 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PPD4.450 | |||
|
PPD4-450AP | |||
|
PPD4.450-FITC | |||
|
PC-PPD4.450 | |||
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