General Information
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Product
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HMGB1 Antibody FITC-Conjugated
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Description
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FITC-Conjugated High mobility group protein B1 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 150-200 on human High mobility group protein B1 protein.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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FITC-Conjugated
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunohistochemistry |
1:50-1:150 |
Immunoprecipitation
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1:200
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Western Blot
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1:2,500-1:5,000
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Protein
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Uniprot #
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P09429
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Overview
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Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids.
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Molecular Function
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bubble DNA binding
chemoattractant activity
C-X-C chemokine binding
cytokine activity
damaged DNA binding
DNA binding, bending
DNA binding transcription factor activity
DNA polymerase binding
double-stranded DNA binding
four-way junction DNA binding
integrin binding
lipopolysaccharide binding
lyase activity
phosphatidylserine binding
RAGE receptor binding
repressing transcription factor binding
RNA binding
single-stranded DNA binding
supercoiled DNA binding
transcription factor binding
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Subcellular Location
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Extracellular region or secreted, nucleus, endosome, plasma membrane, chromosome, cytoplasm, endoplasmic reticulum-golgi intermediate compartment
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Expression
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Ubiquituous. Expressed in platelets.
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Structure
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Belongs to the HMGB family.
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Alternative Nomenclature
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Amphoterin antibody
Chromosomal protein, nonhistone, HMG1 antibody
High mobility group box 1 antibody
High mobility group protein 1 antibody
High mobility group protein B1 antibody
high-mobility group (nonhistone chromosomal) protein 1 antibody
HMG-1 antibody
HMG3 antibody
HMGB 1 antibody
NONHISTONE CHROMOSOMAL PROTEIN HMG1 antibody
SBP 1 antibody
Sulfoglucuronyl carbohydrate binding protein antibody
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