General Information |
|
Product |
Presenilin 1 Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Presenilin 1 (Alzheimer disease 3) Antibody N-epitope |
Verified Applications |
ELISA, IMM, WB |
Host |
Rabbit |
Species Cross Reactivity |
Bovine, Cat, Human, Monkey, Pig |
Immunogen |
Synthetic peptide taken within amino acid region 1-50 on Presenilin 1 (Alzheimer disease 3) protein. |
Accession # |
GenBank: EAW81096.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
1.00-1.25 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Determinant |
N-epitope |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis. |
Molecular Function |
Hydrolase, Protease |
Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface |
Expression |
Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes. |
Structure |
Homodimer |
Alternative Nomenclature |
AD3 antibody FAD antibody Homo Sapiens Clone CC44 Senilin 1 antibody Presenilin-1 CTF12 antibody Protein S182 antibody PS 1 antibody PSEN1 antibody S182 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PSEN.101 | |||
|
PSEN-101AP | |||
|
PSEN.101-FITC | |||
|
PC-PSEN | |||
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