General Information

Product

GPCR GPR15 Antibody

Description

Affinity Purified G-protein coupled receptor 15 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse

Immunogen

Synthetic peptide taken within amino acid region 320-360 on human GPCR GPR15 protein.

Accession #

NCBI: NP_005281

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P49685

Overview

Chemokine receptor; Alternative correceptor with CD4 for HIV-1 infection.

Molecular Function

GPCR; Receptor; Transducer

Subcellular Location

Cell membrane; Multi-pass membrane protein

Structure

Belongs to G-protein coupled receptor 1 family.

Alternative Nomenclature

BOB antibody

Brother of Bonzo antibody

G protein coupled receptor 15 antibody

G protein coupled receptor GPR15 antibody

General Information

Product

MC3 Receptor Antibody

Description

Affinity Purified Melanocortin 3 receptor Antibody Mid-Region

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on MC3r protein.

Accession #

GenBank: AAD41351.1 

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mid-Region

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q01726

Overview

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Membrane

Expression

Cerebellum;testis;Melanocytes and corticoadrenal tissue.

Alternative Nomenclature

BMIQ9 antibody

MC3 antibody

Melanocortin 3 receptor antibody

OB20 antibody

Obesity quantitative trait locus antibody

OQTL antibody

General Information

Product

MC3 Receptor Antibody

Description

Affinity Purified Melanocortin 3 receptor Antibody C-epitope

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on MC3r protein.

Accession #

GenBank: AAO72726.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P41968

Overview

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Membrane

Expression

Brain, placental, and gut tissues.

Structure

Belongs to the G-protein coupled receptor 1 family.

Alternative Nomenclature

BMIQ9 antibody

MC3 antibody

Melanocortin 3 receptor antibody

OB20 antibody

Obesity quantitative trait locus antibody

OQTL antibody

General Information

Product

MC3 Receptor Antibody

Description

Affinity Purified Melanocortin 3 receptor Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on MC3r protein.

Accession #

GenBank: AAD41351.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q01726

Overview

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Membrane

Expression

Cerebellum; testis; Melanocytes and corticoadrenal tissue.

Alternative Nomenclature

BMIQ9 antibody

MC3 antibody

MC3 R antibody

Melanocortin 3 receptor antibody

OB20 antibody

Obesity quantitative trait locus antibody

OQTL antibody

General Information

Product

Nkx2.2 Antibody Affinity Purified

Description

Affinity Purified homeobox protein Nkx-2.2 Antibody C-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

C-epitope synthetic peptide taken within amino acid region 200-273 on human homeobox protein Nkx-2.2

Accession #

NCBI:  NP_002500

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

O95096

Overview

Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).

Molecular Function

Chromatin binding; transcription coactivator activity; Developmental Protein; Transcription regulation; brain development

Subcellular Location

Nucleus

Expression

Interacts with OLIG2

Structure

Belongs to the NK-2 homeobox family.  Contains 1 homeobox DNA-binding domain.  The homeodomain is essential for interaction with OLIG2.

Alternative Nomenclature

Homeobox protein NK 2 homolog B antibody

NK 2 homolog B antibody

NK2 homeobox 2 antibody

NK2 transcription factor like protein B antibody

NK2 transcription factor related locus 2 antibody

NKX2-2 antibody

NKX22 antibody

Nkx2b antibody

tinman antibody

General Information

Product

Nkx2.2 Antibody

Description

Affinity Purified homeobox protein Nkx-2.2 Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

N-epitope synthetic peptide taken within amino acid region 200-250 on human homeobox protein Nkx-2.2.

Accession #

NCBI:  NP_002500

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

O95096

Overview

Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).

Molecular Function

Chromatin binding; transcription coactivator activity; Developmental Protein; Transcription regulation; brain development

Subcellular Location

Nucleus

Expression

Interacts with OLIG2

Structure

Belongs to the NK-2 homeobox family.  Contains 1 homeobox DNA-binding domain.  The homeodomain is essential for interaction with OLIG2.

Alternative Nomenclature

Homeobox protein NK 2 homolog B antibody

NK 2 homolog B antibody

NK2 homeobox 2 antibody

NK2 transcription factor like protein B antibody

NK2 transcription factor related locus 2 antibody

NKX2-2 antibody

NKX22 antibody

Nkx2b antibody

tinman antibody

General Information

Product

TrkA Antibody

Description

Affinity Purified Tyrosine Receptor Kinase A Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 360-410 on human TrkA protein.

Accession #

GenBank: BAA34355.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgY

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P04629

Overview

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.  Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

Molecular Function

Developmental Protein; Kinase; Receptor; Transferase; Tyrosine-protein kinase

Subcellular Location

Cell membrane; Single-pass type I membrane protein; Early & Late endosome membrane

Expression

Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.

Structure

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 2 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 protein kinase domain.

Alternative Nomenclature

CIPA antibody

gp140trk antibody

High affinity nerve growth factor receptor antibody

MTC antibody

Neurotrophic tyrosine kinase receptor type 1 antibody

Ntrk1 antibody

Oncogene TRK antibody

p140-TrkA antibody

Slow nerve growth antibody

TRK antibody

Trk-A antibody

TRK1 antibody

TRK1-transforming tyrosine kinase protein antibody

Tropomyosin-related kinase A antibody

Tyrosine kinase receptor A antibody

General Information

Product

CD56 / NCAM Antibody

Description

Affinity Purified Neural Cell Adhesion Molecule 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 800-847 on human neural cell adhesion molecule 1.

Accession #

GenBank: EAW67208.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

UPI0000EE39A0

Overview

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane.

Molecular Function

Developmental protein; Cell adhesion; Differentiation; Neurogenesis

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.

Alternative Nomenclature

antigen MSK39 identified by monoclonal antibody 5.1H11 antibody

antigen recognized by monoclonal antibody 5.1H11 antibody

CD 56 antibody

CD56 antigen antibody

Cell Adhesion Molecule Neural 1 antibody

MSK39 antibody

N CAM 180 antibody

N-CAM-1 antibody

NCAM 120 antibody

NCAM 140 antibody

NCAM antibody

NCAMC antibody

NCAM1 antibody

Neural cell adhesion molecule 1 antibody

Neural cell adhesion molecule NCAM antibody

General Information

Product

Ephrin Receptor A1 Antibody

Description

Affinity Purified Ephrin type-A receptor 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 55-605 on human Ephrin type-A receptor 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P21709

Overview

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Molecular Function

ATP binding; protein kinase activity; protein kinase binding; transmembrane-ephrin receptor activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Overexpressed in several carcinomas.

Structure

Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA

Alternative Nomenclature

EPH antibody

EPH receptor A1 antibody

Eph tyrosine kinase 1 antibody

EphA1 antibody

Ephrin receptor Eph A1 antibody

Ephrin type-A receptor 1 antibody

EPHT 1 antibody

Erythropoietin producing hepatoma amplified sequence antibody

Esk antibody

Esk antibody

hEpha1 antibody

MGC163163 antibody

Oncogene EPH antibody

Soluble EPHA1 variant 1 antibody

Soluble EPHA1 variant 2 antibody

Tyrosine protein kinase receptor EPH antibody

General Information

Product

Insulin Receptor Antibody

Description

Affinity Purified Insulin receptor alpha and beta Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 900-950 on human Insulin receptor, transcript variant 2 protein. Cross reactive with both Insulin receptor alpha and insulin receptor beta variants.

Accession #

NCBI:  NM_001079817.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P06213

Overview

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.

Structure

Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds.

Alternative Nomenclature

CD220 antibody

HHF5 antibody

HIR A antibody

INSR alpha antibody

Insulin receptor antibody

Insulin receptor subunit alpha antibody

IR antibody

HHF5 antibody

human insulin receptor antibody

Insulin receptor subunit beta antibody

IR 1 antibody