Cell projection › stereocilium membrane; Single-pass type I membrane protein
Expression
Present in the basement membrane of many, but not all tissues. Expressed in retina, cochlea, small and large intestine, pancreas, bladder, prostate, esophagus, trachea, thymus, salivary glands, placenta, ovary, fallopian tube, uterus and testis.
Structure
Interacts with collagen IV and fibronectin via its laminin EGF-like domains. Interaction with collagen may be required for stable integration into the basement membrane. Interacts with USH1C and WHRN. Interacts with NINL. Interacts with PDZD7
Can you tell us please tell us which terminal Usherin Antibody Ush-112AP binds?
USH-112AP will bind to the extra-cellular domain of Usherin isoform A protein, specifically within region 150-180 AA. USH-101AP corresponds to the N-terminal, while USH-121AP binds to the C-terminal. Please let me know if you have any additional questions.