PDE2A1 Blocking Peptide

General Information

Product

PDE2A1 Peptide

Description

Antigenic Blocking Peptide Phosphodiesterase 2A1

Verified Applications

Immunodepletion, Immunocompetition

Peptide Description

Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A1 protein.

Accession #

NCBI:  NP_001230713.1

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

O00408

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.

Isoform PDE2A2: Regulates Mitochondrial cAMP Levels and Respiration.

Molecular Function

Calcium channel activity, cAMP binding, cGMP binding, cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding; protein homodimerization activity; TPR domain binding

Subcellular Location

Cytoplasm

Expression

Expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas.

Structure

Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.

Contains 2 GAF domains.

Alternative Nomenclature

Phosphodiesterase 2A 1