General Information
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Product
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Aurora B Peptide
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Description
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Antigenic Blocking Peptide Aurora Kinase B
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Verified Applications
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Immunodepletion, Immunocompetition
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Immunogen
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Synthetic peptide taken within amino acid region 300-344 on human Aurora Kinase B protein.
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Accession #
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NCBI: NP_004208.2
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q96GD4
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Overview
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Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis.
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Molecular Function
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ATP binding
histone serine kinase activity
kinase binding
metal ion binding
protein serine/threonine/tyrosine kinase activity
protein serine/threonine kinase activity
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Subcellular Location
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Spindle, Nucleus
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Expression
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High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.
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Structure
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Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
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Alternative Nomenclature
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AIK2 antibody
AIM1 antibody
ARK2 antibody
AurB antibody
AURKB antibody
Aurora 1 antibody
Aurora and Ipl1 like midbody associated protein 1 antibody
Aurora kinase B antibody
Aurora related kinase 2 antibody
Aurora- and Ipl1-like midbody-associated protein 1 antibody
Aurora-B antibody
Aurora/IPL1 related kinase 2 antibody
IPL1 antibody
PPP1R48 antibody
Protein phosphatase 1 regulatory subunit 48 antibody
Serine/threonine-protein kinase 12 antibody
Serine/threonine-protein kinase aurora-B antibody
STK1 antibody
STK12 antibody
STK5 antibody
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