General Information

Product

TLR13 Antibody

Description

Affinity Purified Toll-like receptor 13 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 400-480 of mouse TLR13 protein.

Accession #

GenBank: AAI17914.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q6R5N8

Overview

Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

Molecular Function

protein homodimerization activity, rRNA binding

Subcellular Location

endosome membrane, single-pass type I membrane protein

Alternative Nomenclature

Toll like receptor 13 antibody

General Information

Product

TNFAIP3 Antibody

Description

Affinity Purified Tumor necrosis factor alpha-induced protein 3 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 690-790 on human Tumor necrosis factor alpha-induced protein 3.

Accession #

GenBank: AAA51550.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.56-0.62 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P21580

Overview

Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitnase funcitons.  Participates in immune and inflammatory responses signaled by cytokines such as TNF-alpha and IL-1 beta or Toll-like receptors through terminating NF-kappa-B activity.

Molecular Function

Hydrolase, Ligas, Protease, Thiol protease

Subcellular Location

Cytoplasm; Nucleus; Lysosome

Expression

Induced by TNF

Structure

Homodimer

Alternative Nomenclature

A20 antibody

OTU domain containing protein 7C antibody

OTUD7C antibody

Putative DNA binding protein A20 antibody

TNAP3_HUMAN antibody

TNF alpha-induced protein 3 antibody

TNFA1P2 antibody

TNFAIP 3 antibody

Tumor necrosis factor alpha induced protein 3 antibody

Tumor necrosis factor inducible protein A20 antibody

Zinc finger protein A20 antibody

General Information

Product

Phospho-ErbB 2 Antibody

Description

Affinity Purified Receptor tyrosine-protein kinase erB-2 (HER2) Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Predicted: Human

Immunogen

Phoshporylated synthetic peptide taken within amino acid region 1100-1150 on human HER-2 protein

Accession #

GenBank:  AAA75493.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P04626

Overview

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs).

Molecular Function

Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus.

Expression

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Structure

Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG).

Alternative Nomenclature

Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody

c erb B2/neu protein antibody

CD340 antibody

CerbB2 antibody

Erb B2 antibody

Erythroblastosis Virus antibody

HER 2/neu antibody

Herstatin antibody

Metastatic lymph node gene 19 protein antibody

MLN19 antibody

NEU antibody

Neuro Glioblastoma Derived Oncogene Homolog antibody

NGL antibody

p185 ErbB2 antibody

Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody

TKR1 antibody

Tyrosine kinase-type cell surface receptor HER2 antibody

v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) antibody

verbb2 antibody

General Information

Product

FEL D1 Major Allergen I Polypeptide Chain 2 Antibody Affinity Purified

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on feline Major cat allergen I polypeptide chain 2.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P30440

Overview

Causes an allergic reaction in human. Binds to IgE. Major allergen produced by the domestic cat. Implicated as an asthma-inducing agent in human. This protein is sticky and easily adheres to walls, carpet, clothing, furniture and bedding.

Subcellular Location

Secreted; Extracellular region

Expression

Saliva and sebaceous glands.

Structure

Heterotetramer composed of two non-covalently linked disulfide-linked heterodimer of chains 1 and 2.

Alternative Nomenclature

CH1, Fel D1, AG4, Allergen Cat-1, Allergen D I-A, Allergen FDI, Allergen Fel Di, Allregen: Fel d 1-A

General Information

Product

TLR1 Antibody

Description

Affinity Purified Toll-like receptor 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Predicted: Human

Immunogen

Synthetic peptide taken within amino acid region 200-250 on mouse toll-like receptor 1 protein.

Accession #

NCBI:  NP_109607.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.67 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:20,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9EPQ1

Overview

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

Molecular Function

Receptor, Transmembrane signaling receptor activity, triacyl lipopeptide binding

Subcellular Location

Cell membrane; Single-pass type I membrane protein, Cytoplasmic vesicle >  phagosome membrane; Single-pass type I membrane protein

Structure

Binds MYD88 (via TIR domains) (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2 (By similarity). Interacts with CNPY3.

Alternative Nomenclature

CD281 antibody

KIAA0012 antibody

LPRS5 antibody

rsc786 antibody

Similar to Drosophila Toll protein antibody

TIL antibody

TIL. LPRS5 antibody

Tlr1 antibody

Toll (Drosophila) homolog antibody

Toll like receptor 1 antibody

Toll/Interleukin 1 receptor like antibody

General Information

Product

TLR1 Antibody

Description

Affinity Purified Toll-like receptor 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human,

Predicted: Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 370-420 on human Toll-like receptor 1.

Accession #

GenBank: AAI09094.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.67 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:20,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q15399

Overview

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

Molecular Function

Receptor, Transmembrane signaling receptor activity, triacyl lipopeptide binding

Subcellular Location

Cell membrane; Single-pass type I membrane protein, Cytoplasmic vesicle >  phagosome membrane; Single-pass type I membrane protein

Structure

Binds MYD88 (via TIR domains) (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2 (By similarity). Interacts with CNPY3.

Alternative Nomenclature

CD281 antibody

CD281 antigen antibody

KIAA0012 antibody

LPRS5 antibody

rsc786 antibody

Similar to Drosophila Toll protein antibody

TIL antibody

TIL. LPRS5 antibody

Tlr1 antibody

Toll (Drosophila) homolog antibody

Toll like receptor 1 antibody

Toll like receptor 1 Precursor antibody

Toll/Interleukin 1 receptor like antibody

Toll/interleukin-1 receptor-like protein antibody

General Information

Product

FGR Antibody

Description

Affinity Purified Tyrosine-protein kinase, Gardner-Rasheed feline sarcoma viral oncogene homolog Antibody

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 500-529 on human Fgr protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P09769

Molecular Function

Kinase, Transferase, Tyrosine-protein kinase

Subcellular Location

Cell membrane; Lipid anchor, Cytoplasmic side

Expression

Found in neutrophils, monocytes and natural killer cells at protein level.  Found in monocytes and large lymphocytes

Structure

Interacts with ITGB1, ITGB2, MS4A2/FCER1B, FCER1G, FCGR2A or FCGR2B.  Interacts with SYK, FLT3, HCLS1, SIRPA, PTPNS1, CBL, PIK3R1 and FASLG.

Alternative Nomenclature

c fgr protooncogene antibody

c src 2 proto oncogene antibody

FLJ43153 antibody

Gardner Rasheed feline sarcoma viral (v fgr) antibody

MGC75096 antibody

p55 c fgr protein antibody

Proto oncogene c Fgr antibody

SRC 2 antibody

Tyrosine-protein kinase Fgr antibody

General Information

Product

LILRB3 Antibody

Description

Affinity Purified Leukocyte immunoglobulin-like receptor subfamily B member 3 precursor Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 580-631 on human LILRB3 protein.

Accession #

NCBI:  NP_001074919.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.74 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000

ELISA

1:20,000

Western Blot

1:500

Protein

Uniprot #

O75022

Overview

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).

Molecular Function

Receptor, Receptor activity, transmembrane signaling receptor activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Detected in monocytes and B-cells

Alternative Nomenclature

CD85 antigen like family member A antibody

HL9 antibody

IL T5 antibody

Immunoglobulin like transcript 5 antibody

LIR 3 antibody

MGC138403 antibody

Monocyte inhibitory receptor HL9 antibody

PIRB antibody

General Information

Product

LILRB3 Antibody

Description

Affinity Purified Leukocyte immunoglobulin-like receptor subfamily B member 3 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse

Immunogen

Synthetic peptide taken within amino acid region 800-841 on mouse LILRB3 protein.

Accession #

NCBI:  NP_035225.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.74 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000

ELISA

1:20,000

Western Blot

1:500

Protein

Uniprot #

P97484

Overview

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).

Subcellular Location

Cell membrane, single-pass type I membrane protein

Expression

Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells.

Alternative Nomenclature

CD85 antigen like family member A antibody

HL9 antibody

IL T5 antibody

Immunoglobulin like transcript 5 antibody

LIR 3 antibody

MGC138403 antibody

Monocyte inhibitory receptor HL9 antibody

PIRB antibody

General Information

Product

PKC epsilon Antibody

Description

Affinity Purified Protein Kinase C epsilon Antibody Mid-Region Epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 350-400 on human Protein Kinase C epsilon type protein.

Accession #

NCBI:  NP_005391.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mid-Region Epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q02156

Overview

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardio myocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAP, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implication the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaciton with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a rolei n the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). invovled in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be invovled in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin-and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. IS able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines produciton. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm; Cell Membrane; Nucleus

Structure

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

Contains 1 AGC-kinase C-terminal

Contains 1 C2 domain.

Contains 2 phorbol-ester/DAG-type zinc fingers.

Contains 1 protein kinase domain.

Alternative Nomenclature

KPCE_HUMAN antibody

MGC125656 antibody

MGC125657 antibody

nPKC epsilon antibody

nPKC-epsilon antibody

PKCE antibody

Pkcea antibody

PRKCE antibody

Protein kinase C epsilon antibody