General Information

Product

SLC9A3 Antibody

Description

Affinity Purified Sodium/hydrogen exchanger 3 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acids within region 590-640 on human SLC9A3 protein.

Physical Properties

Quantity

100 ug

Concentration

0.5-1.5 ﾵg/ﾵl in antibody stabilization buffer

Immunoglobulin

IgG

Conjugate

Unconjugated

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20ﾡC for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:50-1:100

Immunofluorescence

1:50-1:100

Immunohistochemistry

1:50-1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P48764

Molecular Function

PDZ domain binding

potassium:proton antiporter activity

sodium:proton antiporter activity

Subcellular Location

Plasma membrane

Alternative Nomenclature

MGC126718 antibody

Na(+)/H(+) exchanger 3 antibody

NHE 3 antibody

SLC9A 3 antibody

Sodium / Hydrogen Exchanger 3 antibody

Sodium/hydrogen exchanger, apical epithelial antibody

Solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 antibody

Solute carrier family 9 (sodium/hydrogen exchanger), member 3 antibody

Solute carrier family 9 member 3 antibody

General Information

Product

Nicotinic Acetylcholine Receptor alpha 7 Antibody

Description

Affinity Purified Neuronal acetylcholine receptor subunit alpha-7 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Rat

Immunogen

Synthetic peptide corresponding to exon 5 of alpha 7-2 nAChRs protein.

Accession #

GenBank: XP_008757720

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:250

Protein

Uniprot #

Q05941

Overview

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Molecular Function

Ion channel, Ligand-gated ion channel, Receptor

Subcellular Location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Structure

Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.

Alternative Nomenclature

7nAChR antibody

A7 nicotinic acetylcholine receptor antibody

alpha-7 subunit antibody

AChR antibody

Acra7 antibody

Alpha 7 neuronal nicotinic acetylcholine receptor antibody

Alpha7 antibody

Alpha7 nicotinic receptor antibody

Cholinergic receptor nicotinic alpha 7 antibody

CHRNA7 antibody

CHRNA7-2 antibody

NACHRA 7 antibody

Neuronal acetylcholine receptor protein alpha 7 chain precursor antibody

Nicotinic acetylcholine alpha 7 subunit antibody

Schizophrenia neurophysiologic defect candidate antibody

General Information

Product

Bestrophin 4 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, D. melanogaster

Immunogen

Synthetic peptide taken within amino acid region 400-500 on human Bestrophin 4 protein.

Accession #

NCBI:  NP_695006.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Immunoprecipitation

1:200

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q8NFU0

Overview

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Molecular Function

Chloride Channel

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta.

Structure

Belongs to bestrophin Family

Alternative Nomenclature

BEST 4 antibody

MGC126872 antibody

Vitelliform macular dystrophy 2 like 2 antibody

VMD2-like gene 2 antibody

VMD2L2 antibody

General Information

Product

Bestrophin 4 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 400-500 on Bestrophin 4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Immunoprecipitation

1:200

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q8NFU0

Overview

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Molecular Function

Chloride Channel

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta.

Structure

Belongs to bestrophin Family

Alternative Nomenclature

BEST 4 antibody

MGC126872 antibody

Vitelliform macular dystrophy 2 like 2 antibody

VMD2-like gene 2 antibody

VMD2L2 antibody

General Information

Product

Bestrophin 2 Antibody

Verified Applications

CM, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 388-404 of Mouse Bestrophin 2 protein, peptide was covalently modified.

Sequence:

EVHGDFLQRLLPAGAGS

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q8BGM5

Overview

Forms calcium sensitive chloride channels. Highly permeable to bicarbonate.

Molecular Function

Ion transport; Sensory transduction; Transport

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Retinal pigment epithelium and colon

Structure

Belongs to Bestrophin Family

Alternative Nomenclature

BEST 2 antibody

Vitelliform macular dystrophy 2 homolog antibody

Vitelliform macular dystrophy 2 like 1 antibody

VMD2L1 antibody

General Information

Product

Aquaporin 1 Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 215-265 on human Aquaporin 1 protein.

Accession #

GenBank:  AAL87136

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.59 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P29972

Overview

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Molecular Function

Blood group antigen; Transport

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.

Structure

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Alternative Nomenclature

AQP 1 antibody

AQP CHIP antibody

aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group) antibody

Aquaporin CHIP antibody

Aquaporin-1 antibody

Channel forming integral protein 28kDa antibody

Channel like integral membrane protein 28 kDa antibody

CHIP 28 antibody

CO antibody

Colton blood group antibody

Growth factor induced delayed early response protein antibody

MGC26324 antibody

Urine water channel antibody

Water channel protein CHIP 29 antibody

Water channel protein for red blood cells and kidney proximal tubule antibody

General Information

Product

Aquaporin 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on human Aquaporin 2 protein.

Accession #

GenBank: CAG46821.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.62 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P34080

Overview

Forms a water-specific channel that provies the plasma mebranes of red cells and kidney proximal tubules with water permeability.

Molecular Function

Transport

Subcellular Location

Apical cell membrane; Multiplass membrane protein; Basolateral cell membrane

Expression

Renal collecting tubule

Structure

Contain two tandem repeats each with three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala

Alternative Nomenclature

ADH water channel antibody

AQP 2 antibody

AQP CD antibody

Aquaporin 2 collecting duct antibody

Aquaporin CD antibody

Collecting duct water channel protein antibody

MGC34501 antibody

Water channel aquaporin 2 antibody

Water channel protein for renal collecting duct antibody

WCH CD antibody

General Information

Product

Aquaporin 3 Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on rat Aquaporin 3 protein.

Accession #

GenBank: CAG46822.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.57 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P47862

Overview

Promotes glycerol permeability and water transport across cell membranes.  Plays important role in regulating stratum corneum and epidermal glyceral content.  Involved in skin hydration, wound healing and tumorigenesis.

Molecular Function

Transport

Subcellular Location

Membrane; Multi-pass protein

Expression

Renal medulla and colon.

Structure

Contain two tandem repeats each with three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala

Alternative Nomenclature

AQP 3 antibody

Aquaglyceroporin-3 antibody

Aquaporin 3 (GIL blood group) antibody

Aquaporin-3 antibody

GIL antibody

Gill blood group antibody

General Information

Product

Aquaporin 4 Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-323 on rat Aquaporin 4 protein.

Accession #

NCBI:  NP_001641

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.62 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P55087

Overview

Forms water specific channel. Osmoreceptor which regulates water balance and mediates water flow within CNS.

Molecular Function

Transport

Subcellular Location

Membrane; Multi-pass protein

Expression

Abundant in mature brain but only weakly detectable in eye, kidney, intestine, and lung.

Structure

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Alternative Nomenclature

AQP 4 antibody

Aquaporin type 4 antibody

Aquaporin-4 antibody

HMIWC2 antibody

Mercurial insensitive water channel antibody

MGC22454 antibody

MIWC antibody

WCH 4 antibody

General Information

Product

Aquaporin 5 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 250-299 on rat Aquaporin 5 protein.

Accession #

GenBank: AAH78904

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.65 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q6AYU6

Overview

Forms a water-specific channel and is osmoreceptor which regulates body water balance and mediates water flow ithin the CNS.

Molecular Function

Transport

Subcellular Location

Membrane; Multi-pass protein

Expression

Expressed predominantly in the ependymal cell lining the aqueductal system and over the space of the brain in contact with subarachnoid space.  Weakly detectable in eye, kidney, intestine and lung.

Structure

Contain two tandem repeats each with three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala

Alternative Nomenclature

AQP 5 antibody

Aquaporin 5 antibody