General Information

Product

GRK6 Antibody

Description

Affinity Purified G protein-coupled receptor kinase 6 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 500-550 on human G protein-coupled receptor kinase 6 protein.

Accession #

NCBI:  NP_002073

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P43250

Overview

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

Molecular Function

ATP binding

beta-adrenergic receptor kinase activity

G-protein coupled receptor kinase activity

Subcellular Location

Membrane; Lipid-anchor

Expression

Widely expressed.

Structure

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

Alternative Nomenclature

G protein coupled receptor kinase 6 antibody

G protein coupled receptor kinase GRK6 antibody

Gprk6 antibody

Grk6 antibody

General Information

Product

DWORF Antibody

Description

Affinity Purified Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synththetic peptide corresponding to full length Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P0DN83

Overview

Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity. Does not directly stimulates SERCA pump activity. Enhances sarcoplasmic reticulum Ca2+ uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN).

Molecular Function

Sarcoplasmic reticulum membrane; Single-pass membrane protein

Alternative Nomenclature

Dwarf open reading frame antibody

DWORF antibody

Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator

DWORFSERCA regulator DWORF antibody

General Information

Product

Angiopoietin-like 4 Antibody

Description

Affinity Purified Angiopoietin-related protein 4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse

Immunogen

Synthetic peptide taken within amino acid region 50-100 on mouse Angiopoietin-related protein 4.

Accession #

NCBI:  NP_065606.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q9Z1P8

Overview

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Molecular Function

enzyme inhibitor activity

identical protein binding

Subcellular Location

Secreted

Expression

Predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver.

Structure

Coiled coil, Signal

Alternative Nomenclature

Angiopoietin like 4 antibody

Angiopoietin-like protein 4 antibody

ANGPT L2 antibody

ANGPT L4 antibody

Angptl4 antibody

ARP4 antibody

Fasting induced adipose factor antibody

FIAF antibody

HARP antibody

Hepatic angiopoietin related protein antibody

Hepatic fibrinogen/angiopoietin-related protein antibody

HFARP antibody

NL2 antibody

Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein antibody

PGAR antibody

pp1158 antibody

PPARG angiopoietin related protein antibody

PSEC0166 antibody

TGQTL antibody

UNQ171 antibody

Weakly similar to angiopoietin 1 [H.sapiens] antibody

General Information

Product

Twist Antibody

Description

Affinity Purified Twist-related protein 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide take within amino acid region 50-100 on human Twist-related protein 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polylclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q15672

Subcellular Location

Nucleus

Expression

Subset of mesodermal cells.

Alternative Nomenclature

ACS3 antibody

B-HLH DNA binding protein antibody

bHLHa38 antibody

BPES2 antibody

BPES3 antibody

Class A basic helix-loop-helix protein 38 antibody

CRS antibody

CRS1 antibody

CSO antibody

H-twist antibody

SCS antibody

Twist basic helix loop helix transcription factor 1 antibody

Twist family bHLH transcription factor 1 antibody

Twist homolog 1 (Drosophila) antibody

Twist homolog 1 antibody

Twist related protein 1 antibody

TWIST1 antibody

General Information

Product

CGRP Antibody

Description

Affinity Purified Calcitonin gene-related peptide 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acids within region 350-410 mouse Calcitonin gene-related peptide 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20?C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500-1:5,000

Protein

Uniprot #

Q99JA0

Overview

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity).`

Molecular Function

calcitonin receptor binding

hormone activity

signaling receptor binding

Subcellular Location

Secreted

Expression

Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult.

Structure

Belongs to the calcitonin family.

Alternative Nomenclature

Calcitonin/calcitonin related polypeptide alpha antibody

Alpha type CGRP antibody

Beta type CGRP antibody

CALC1 antibody

CALC2 antibody

CALCA antibody

CALCB antibody

Calcitonin 1 antibody

Calcitonin 2 antibody

Calcitonin gene related peptide I antibody

Calcitonin gene related peptide II antibody

Calcitonin related polypeptide alpha antibody

Calcitonin related polypeptide beta antibody

CGRP antibody

CGRP1 antibody

CGRP2 antibody

CT antibody

Katacalcin antibody

KC antibody

General Information

Product

Phospho-Cofilin Antibody

Description

Affinity Purified Phosphorylated Cofilin Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acids within region 1-50 on human Phosphorylated Cofilin.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Modification

Phosphorylated

Storage

-20?C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500-1:5,000

Protein

Uniprot #

P23528

Overview

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity).

Molecular Function

actin filament binding

Subcellular Location

Plasma membrane, Cytoskeleton, Nucleus

Expression

Widely distributed in various tissues.

Structure

Belongs to the actin-binding proteins ADF family.

Alternative Nomenclature

18 kDa phosphoprotein antibody

CFL 1 antibody

CFL antibody

CFL1 antibody

COF1_HUMAN antibody

Cofilin 1 antibody

Cofilin 1 non muscle antibody

Cofilin antibody

Cofilin non muscle isoform antibody

Cofilin-1 antibody

epididymis secretory protein Li 15 antibody

HEL-S-15 antibody

non-muscle isoform antibody

p18 antibody