General Information

Product

SREBP1 Antibody Affinity Purified

Description

Affinity Purified Sterol regulatory element-binding protein 1 Antibody

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 950-1000 on human Sterol regulatory element binding transcription factor 1 protein.

Accession #

GenBank: AAH63281.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P36956

Overview

Transcriptional activator required for lipid homeostasis.

Molecular Function

Activator

Subcellular Location

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane, Nucleus

Expression

liver, adrenal gland, lung, ovary, hepatoma cell lines, kidney, brain, white fat, and muscle.

Structure

Belongs to the SREBP family

Alternative Nomenclature

ADD 1 antibody

Class D basic helix-loop-helix protein 1 antibody

Processed sterol regulatory element-binding protein 1 antibody

SREBF 1 antibody

SREBP1 antibody

Sterol regulatory element-binding transcription factor 1 antibody

General Information

Product

UCN2 Antibody Affinity Purified

Description

Affinity Purified Urocortin-2 preprotein Antibody

Verified Applications

ELISA, SB, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken wtihin amino acid region 70-115 of human Urocortin 2 protein.

Accession #

NCBI:  NP_149976.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.71 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q96RP3

Overview

Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

Molecular Function

Hormone binding, receptor binding, hormone

Subcellular Location

Secreted

Expression

Binds with high affinity to CRF receptors 2-alpha and 2-beta.

Alternative Nomenclature

SRP

Stresscopin-related peptide

Ucn II

UCN2

UCNI

UR

Urocortin II

Urocortin-2

Urocortin-related peptide

URP

General Information

Product

ULK1 Antibody

Description

Affinity Purified Serine/Threonine-protein kinase ULK1 Antibody

Verified Applications

ELISA, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Panda

Immunogen

Synthetic peptide taken within amino acid region 1000-1050 on mouse ULK1 protein.

Accession #

NCBI:  NP_003556.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:250

Protein

Uniprot #

O75385

Overview

Involved in autophagy in response to starvation. Plays a role early in neuronal differentiation and is required for granule cell axon formation.

Molecular Function

ATP Binding, protein serine/threonine kinase activity, Rab GTPase binding, protein complex binding

Subcellular Location

Cytoplasm, cytosol, preautphagosomal structure. (Note: under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome)

Expression

Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.

Alternative Nomenclature

ATG1 autophagy related 1 homolog antibody

ATG1A antibody

Autophagy related protein 1 homolog antibody

hATG1 antibody

Serine/threonine-protein kinase ULK1 antibody

ULK1 antibody

Unc 51 like kinase 1 antibody

Unc-51 like kinase 1 (C. elegans) antibody

UNC51 antibody

General Information

Product

TIE2 Antibody

Description

Affinity Purified Tyrosine-protein kinase receptor Tie-1 isoform 2 Antibody

Verified Applications

DB, ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 540-590 on human Tyrosine-protein kinase receptor Tie-1 isoform 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q02763

Overview

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Integral component of membrane

Expression

Detected in umbilical vein endothelial cells. Proteolytic processing gives rise to a soluble extracellular domain that is detected in blood plasma (at protein level). Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.

Structure

Belongs to the protein kinase superfamily. Tyr protein kinase family.  Contains protein kinase domain.

Alternative Nomenclature

Angiopoietin 1 receptor antibody

CD202b antibody

Endothelial tyrosine kinase antibody

Endothelium specific receptor tyrosine kinase 2 antibody

Hyk antibody

p140 TEK antibody

TEK antibody

tek tyrosine kinase antibody

TIE 2 antibody

Tunica interna endothelial cell kinase antibody

Tyrosine kinase with Ig and EGF homology domains 2 antibody

Tyrosine protein kinase receptor TEK antibody

Tyrosine protein kinase receptor TIE 2 antibody

Venous malformations multiple cutaneous and mucosal antibody

VMCM 1 antibody

VMCM antibody

General Information

Product

Soluble Guanylyl Cyclase beta 1 Antibody

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Mouse, Pig, Rat

Immunogen

Synthetic peptide taken within amino acid region 175-225 on rat guanylate cyclase soluble subunit beta-1 protein.

Accession #

GenBank: AAA41204.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.2 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P20595

Molecular Function

Lyase, GTP binding, heme binding

Subcellular Location

Cytoplasm

Expression

Lung and brain

Structure

Heterodimer of an alpha and a  beta chain.  Homotetramer; dimer of dimers (in vitro).

Alternative Nomenclature

GC-S-beta-1 antibody

GC-SB3 antibody

GCbeta1 antibody

GCS beta 3 antibody

guanylate cyclase 1, soluble, beta 3 antibody

Guanylate cyclase soluble beta 1 chain antibody

GUC1B3 antibody

GUCY1B1 antibody

SGC antibody

Soluble guanylate cyclase small subunit antibody

General Information

Product

Myeloperoxidase Antibody

Description

Affinity Purified Myeloperoxidase Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 290-340 human Myeloperoxidase protein.

Accession #

GenBank: AAB25582.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.2 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P05164

Overview

Is a component of the host defense system of polymorphonuclear leukocytes.  Is responsible for the microbicidal activity against a range of organisms.

Molecular Function

Oxireductase, Peroxidase, chromatin binding

Alternative Nomenclature

84 kDa myeloperoxidase antibody

MPO antibody

Myeloperoxidase heavy chain antibody

Myeloperoxidase light chain antibody

General Information

Product

PDE8A Antibody

Description

Affinity Purified Pan Phosphodiesterase 8A Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Rat

Immunogen

Synthetic cyclic peptide from near the N terminus common to all PDE8A variants.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500-1:2,000

Protein

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity, Hydrolase, Metal-binding

Subcellular Location

Cytosol

Expression

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Structure

Belongs to cyclic nucleotide phosphodiesterase family. PDE8B subfamily.  Contains 1 PAC (Pas-associated C-terminal) domain.  Contains 1 PAS (PER-ARNT-SIM) domain.

Alternative Nomenclature

5''-cyclic phosphodiesterase 8A antibody

cAMP specific cyclic nucleotide phosphodiesterase 8A antibody

FLJ16150 antibody

High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A antibody

HsT19550 antibody

PDE 8A antibody

Phosphodiesterase 8A antibody

Weakly similar to 3'5'-cyclic-nucleotide phosphodiesterase antibody

General Information

Product

PDE8A Antibody

Description

Affinity Purified Pan Phosphodiesterase 8A Antibody Mid-Region

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Rat

Immunogen

Synthetic cyclic peptide from mid-region common to all PDE8A variants.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mid-Region

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500-1:2,000

Protein

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity, Hydrolase, Metal-binding

Subcellular Location

Cytosol

Expression

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Structure

Belongs to cyclic nucleotide phosphodiesterase family. PDE8B subfamily.  Contains 1 PAC (Pas-associated C-terminal) domain.  Contains 1 PAS (PER-ARNT-SIM) domain.

Alternative Nomenclature

5''-cyclic phosphodiesterase 8A antibody

cAMP specific cyclic nucleotide phosphodiesterase 8A antibody

FLJ16150 antibody

High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A antibody

HsT19550 antibody

PDE 8A antibody

Phosphodiesterase 8A antibody

Weakly similar to 3'5'-cyclic-nucleotide phosphodiesterase antibody

General Information

Product

PDE8A Antibody

Description

Affinity Purified Pan Phosphodiesterase 8A Antibody C-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Rat

Immunogen

Synthetic cyclic peptide from C terminus common to all PDE8A variants.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

Molecular Function

3',5'-cyclic-AMP phosphodiesterase activity, Hydrolase, Metal-binding

Subcellular Location

Cytosol

Expression

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Structure

Belongs to cyclic nucleotide phosphodiesterase family. PDE8B subfamily.  Contains 1 PAC (Pas-associated C-terminal) domain.  Contains 1 PAS (PER-ARNT-SIM) domain.

Alternative Nomenclature

5''-cyclic phosphodiesterase 8A antibody

cAMP specific cyclic nucleotide phosphodiesterase 8A antibody

FLJ16150 antibody

High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A antibody

HsT19550 antibody

PDE 8A antibody

Phosphodiesterase8A antibody

Weakly similar to 3'5' cyclic nucleotide phosphodiesterase antibody

General Information

Product

PGCA Antibody

Description

Affinity Purified Atrial natriuretic peptide receptor 1 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to C terminal amino acids 1042-1057 of Human PGCA.

Seqence:

VRTYWLLGERGCSTRG

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.85 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:25-1:250

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:25-1:250

Immunofluorescence

1:25-1:250

Immunohistochemistry

1:25-1:250

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P16066

Overview

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Molecular Function

ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Homodimer

Alternative Nomenclature

ANP A antibody

Atrial natriuretic peptide A type receptor antibody

Atrial natriuretic peptide receptor 1 antibody

GC A antibody

GC-A antibody

Guanylate cyclase A antibody

NPR 1 antibody

NPR A antibody