General Information

Product

CXCR5 Antibody Affinity Purified

Description

Affinity Purified Chemokine (C-X-C motif) receptor 5 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 320-370 on human Chemokine (C-X-C motif) receptor 5 protein.

Accession #

Gen Bank: AAI10353.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

.50-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q2YD84

Overview

Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.

Molecular Function

B-cell activation.

Subcellular Location

Integral component of plasma membrane; External side of plasma membrane

Expression

Expression in mature B-cells and Burkitt lymphoma cells

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

BLR 1 antibody

Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5) antibody

C X C chemokine receptor type 5 antibody

CD 185 antibody

Chemokine receptor 5 antibody

CXC chemokine receptor type 5 antibody

CXCR-5 antibody

MDR 15 antibody

MGC117347 antibody

Monocyte-derived receptor 15 antibody

General Information

Product

PDE2A Antibody

Description

Affinity Purified Phosphodiesterase 2A, cGMP-stimulated Antibody C-epitope

Verified Applications

CM, ELISA, FRET, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique C-terminal amino acid sequence on PDE2A gene.

Accession #

GenBank: EAW74861.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250-1:1,000

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250-1:1,000

Immunofluorescence

1:150-1:1,000

Immunohistochemistry

1:250-1:1,000

Immunoprecipitation

1:200

Western Blot

1:250-1:1,000

Protein

Uniprot #

UPI000003B340

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Molecular Function

Hydrolase, cAMP, cGMP, Metal-binding, Angiogenesis

Subcellular Location

Multi-pass membrane protein

Expression

bundant in adipose tissues.

Structure

Interacts with PIK3CG. Interacts with RAPGEF3 and PIK3R6.

Alternative Nomenclature

5''-cyclic phosphodiesterase antibody

cGMP dependent 3'5' cyclic phosphodiesterase antibody

cGMP stimulated phosphodiesterase 1 antibody

cGMP stimulated phosphodiesterase 4 antibody

cGMP-dependent 3'' antibody

CGS PDE antibody

Cyclic GMP stimulated phosphodiesterase antibody

PDE 2A antibody

PDE 2A1 antibody

PDE 2A4 antibody

PDE2A antibody

Phosphodiesterase 2A cGMP stimulated antibody

General Information

Product

PDE2A Antibody

Description

Affinity Purified Phosphodiesterase 2A, cGMP-stimulated Antibody N-epitope

Verified Applications

CM, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on PDE2A gene.

Accession #

GenBank: EAW74861.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:250-1:1,000

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:250-1:1,000

Immunofluorescence

1:150-1:1,000

Immunohistochemistry

1:250-1:1,000

Immunoprecipitation

1:200

Western Blot

1:250-1:1,000

Protein

Uniprot #

UPI000003B340

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Molecular Function

Hydrolase, cAMP, cGMP, Metal-binding, Angiogenesis

Subcellular Location

Multi-pass membrane protein

Expression

bundant in adipose tissues.

Structure

Interacts with PIK3CG (By similarity). Interacts with RAPGEF3 and PIK3R6.

Alternative Nomenclature

5''-cyclic phosphodiesterase antibody

cGMP dependent 3'5' cyclic phosphodiesterase antibody

cGMP stimulated phosphodiesterase 1 antibody

cGMP stimulated phosphodiesterase 4 antibody

cGMP-dependent 3'' antibody

CGS PDE antibody

Cyclic GMP stimulated phosphodiesterase antibody

PDE 2A antibody

PDE 2A1 antibody

PDE 2A4 antibody

PDE2A antibody

Phosphodiesterase 2A cGMP stimulated antibody

General Information

Product

Insulin degrading enzyme Antibody

Verified Applications

ELISA, IP WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 100-150 on human Insulin-degrading enzyme protein.

Accession #

GenBank: EAW50092.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

UPI00002289E9

Overview

Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.

Molecular Function

ATPase activity; Ubiquitin Binding; Zinc ion binding; Insulin binding; Hydrolase; Metalloprotease; Protease

Subcellular Location

Cytoplasm; Cell membrane; Secreted

Structure

Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus.

Alternative Nomenclature

Abeta-degrading protease antibody

FLJ35968 antibody

Ide antibody

insulin protease antibody

Insulin-degrading enzyme antibody

insulinase antibody

insulysin antibody

General Information

Product

Integrin beta 3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human Integrin Beta 3 subunit protein.

Accession #

GenBank: AAB23689.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P05106

Overview

Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Molecular Function

Cell adhesion, Host-virus interaction

Subcellular Location

Cell junction, Cell membrane, Cell projection, Membrane

Expression

Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Structure

Heterodimer of an alpha and a beta subunit. Beta-3 (ITGB3) associates with either alpha-IIb (ITGA2B) or alpha-V (ITGAV). Isoform Beta-3C interacts with FLNB. Interacts with COMP. Interacts with PDIA6 following platelet stimulation. Interacts with SYK; upon activation by ITGB3 promotes platelet adhesion. Interacts with MYO10. Interacts with DAB3. Interacts with FERMT2. Interacts with EMP2; regulates the levels of the heterodimer ITGA5:ITGB3 integrin expression on the plasma membrane (PubMed:16216233). Integrin ITGAV:ITGB3 interacts with FBLN5 (via N-terminus). Integrin ITGAV:ITGB3 interacts with herpes virus 8/HHV-8 glycoprotein B and acts as a receptor for the virus. Interacts with HIV-1 Tat.

Alternative Nomenclature

BDPLT16 antibody

BDPLT2 antibody

CD61 antibody

GP3A antibody

GT antibody

HPA 1 antibody

HPA 4 antibody

Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody

Integrin beta chain beta 3 antibody

ITGB 3 antibody

NAIT antibody

Platelet fibrinogen receptor, beta subunit antibody

Platelet glycoprotein IIIa antibody

Platelet membrane glycoprotein IIIa antibody

PTP antibody

General Information

Product

Phospho PGCA Antibody

Description

Affinity Purified Atrial Natriuretic peptide receptor 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 500-550 on human Atrial natriuretic peptide receptor 1 protein.

Accession #

NCBI:  XP_011507887.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P16066

Overview

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

Molecular Function

ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Homodimer

Alternative Nomenclature

ANP A antibody

ANPR-A antibody

Atrial natriuretic peptide A type receptor antibody

Atrial natriuretic peptide receptor 1 antibody

Atrionatriuretic peptide receptor A antibody

GC A antibody

Guanylate cyclase A antibody

Guanylate cyclase antibody

GUC2A antibody

Natriuretic peptide A type receptor antibody

Natriuretic peptide receptor A/guanylate cyclase A antibody

NPR 1 antibody

NPR A antibody

General Information

Product

LAMP2 Antibody

Description

Affinity Purified Lysosome-associated membrane glycoprotein 2 Antibody

Verified Applications

DB, ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Predicted: Rat

Immunogen

Synthetic peptide taken within amino acid region 260-310 on human lysosomal membrane glycoprotein-2.

Accession #

GenBank: AAB41647.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P13473

Overview

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion

Molecular Function

enzyme binding

Subcellular Location

Cell membrane, Endosome, Lysosome, Membrane

Expression

LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle.LAMP-2B is highly expressed in skeletal muscle, less in brain, placenta, lung, kidney and pancreas, very low in liver.

Structure

Belongs to the LAMP family

Alternative Nomenclature

CD107 antigen-like family member B antibody

CD107b antibody

LAMP 2 antibody

LAMP 2C antibody

LAMPB antibody

LGP110 antibody

Lysosome associated membrane protein 2 antibody

MAC3 antibody

General Information

Product

MIG7 Antibody Affinity Purified

Description

Affinity Purified MIG7 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 170-220 on MIG7 protein.

Accession #

GenBank: ABF71424.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.68 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q1AHR6

Alternative Nomenclature

mig 7 antibody

General Information

Product

MRP1 Antibody

Description

Affinity Purified Multidrug resistance-associated protein 1 Antibody

Verified Applications

ELISA, IP, IHC, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequences on rat multidrug resistance-associated protein 1.

Accession #

NCBI:  NP_071617.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:20,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q8CG09

Overview

Mediates export of organic anions and drugs from the cytoplasm.

Molecular Function

Hydrolase

Subcellular Location

Cell membrane, Membrane

Expression

Skeletal muscle, brain, heart, spleen, lung and kidney.

Structure

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.

Alternative Nomenclature

ABC29 antibody

ABCC antibody

ABCC1 antibody

ATP binding cassette sub family C (CFTR/MRP) member 1 antibody

ATP binding cassette sub-family C member 1 antibody

DKFZ antibody

General Information

Product

P2Y12 Antibody

Description

P2Y purinoceptor 12 Antibody

Verified Applications

Cell labeling, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chimpanzee, Human, Monkey, Porcine, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-342 on human P2Y12 protein.

Accession #

NCBI:  NP_795345.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57-0.68 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9H224

Overview

Serves as a receptor for ADP and ATP that is coupled to G-proteins that inhibit the adenylyl cyclase second messenger system.  It is necessary for platelet aggregation and blood coagulation.

Molecular Function

G-protein coupled receptor, Transducer, ADP-receptor activity

Subcellular Location

Cell membrane; Multipass membrane protein

Expression

It is highly expressed in the platelets with lower levels of expression found in the brain, and is also expressed in the spinal cord and fetal brain.  The lowest levels of expression are found in the lung, appendix, pituitary and adrenal gland.

Alternative Nomenclature

ADP glucose receptor antibody

ADPG R antibody

ADPGR antibody

BDPLT8 antibody

G protein coupled receptor SP1999 antibody

Gi coupled ADP receptor HORK 3 antibody

HORK 3 antibody

P2RY 12 antibody

P2T(AC) antibody

P2Y 12 antibody

P2Y purinoceptor 12 antibody

P2Y(ADP) antibody

P2Y(cyc) antibody

P2Y12 antibody

P2Y12 platelet ADP receptor antibody

Platelet ADP receptor antibody

Purinergic receptor P2RY12 antibody

Purinergic receptor P2Y G protein coupled 12 antibody

Purinergic receptor P2Y12 antibody

Putative G protein coupled receptor antibody

SP 1999 antibody