General Information |
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Product |
Phospho-MERTK Positive Control |
Description |
Western Blot Positive Control Phosphorylated Tyrosine-protein kinase Mer |
Verified Applications |
WB |
Accession # |
NCBI: NP_075232.1 |
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Quantity |
5 Applications |
Volume |
Inquire |
Concentration | The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel. |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Uniprot # |
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Overview |
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. |
Molecular Function |
Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Membrane; Single-pass type I membrane protein |
Structure |
Interacts (upon activation) with TNK2; stimulates TNK2 autophosphorylation. Interacts (via N-terminus) with extracellular ligands LGALS3, TUB, TULP1 and GAS6. Interacts with VAV1 in a phosphotyrosine-independent manner. |
Alternative Nomenclature |
c MER antibody c mer proto oncogene tyrosine kinase antibody Eyk antibody MER antibody MERPEN antibody Mertk antibody MERTK c-mer proto-oncogene tyrosine kinase antibody MGC133349 antibody nmf12 antibody Nyk antibody Proto oncogene tyrosine protein kinase MER antibody Receptor tyrosine kinase MerTK antibody RP38 antibody STK kinase antibody Tyrosine-protein kinase Mer antibody |
Protein information supplied by UniProt
FabGennix Phospho-MerTK Antibody has been used in 26 Publications
Applications: Confocal microscopy, Flow cytometry, Immunocytochemistry, Immunohistochemistry Immunofluorescence, and Western blot
Reactivity: Human, Mouse, and Rat
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ZCai, Bishuang, et al. "MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity." Sci. Signal. 11.549 (2018). |
PMID: 30254055 Applications: Western Blot Reactivity: Human |
Zhang, Bing, et al. "Mer receptor tyrosine kinase negatively regulates lipoteichoic acid-induced inflammatory response via PI3K/Akt and SOCS3." Molecular immunology 76 (2016).
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PMID: 27419619 Applications: Western Blot Reactivity: Mouse |
Das, Amitava, et al. "Correction of MFG-E8 resolves inflammation and promotes cutaneous wound healing in diabetes." The Journal of Immunology 196.12 (2016).
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PMID: 27194784 Applications: Western Blot Reactivity: Mouse |
Cai, Bishuang, et al. "MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation." Proceedings of the National Academy of Sciences 113.23 (2016).
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PMID: 27199481 Applications: Western Blot Reactivity: Mouse |
Ginisty, Aurélie, et al. "Evidence for a Subventricular Zone Neural Stem Cell Phagocytic Activity Stimulated by the Vitamin K‐Dependent Factor Protein S." STEM CELLS 33.2 (2015).
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PMID: 25308179 Applications: Western Blot Reactivity: Rat |
Nguyen, Khanh-Quynh N., et al. "Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity." Journal of Biological Chemistry 289.37 (2014).
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PMID: 25074939 Applications: Western Blot Reactivity: Human |
Law, Ah-Lai, et al. "Cleavage of Mer Tyrosine Kinase (MerTK) from the Cell Surface Contributes to the Regulation of Retinal Phagocytosis." Journal of Biological Chemistry (2014). |
PMID: 25538233 Applications: Western Blot Reactivity: Mouse
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Suleiman, Lutfi, Claude Négrier, and Habib Boukerche. "Protein S: A multifunctional anticoagulant vitamin K-dependent protein at the crossroads of coagulation, inflammation, angiogenesis, and cancer." Critical Reviews in oncology/hematology 88.3 (2013).
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PMID: 23065156 Applications: Western Blot Reactivity: Mouse
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Wang, Y, et al. "Mer Receptor Tyrosine Kinase Promotes Invasion and Survival In Glioblastoma Multiforme." Oncogene 32.7 (2013): 872-882. |
PMID: 22469987 Applications: Confocal Microscopy, Immunofluorescence, Immunohistochemistry, Western Blot Reactivity: Human
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Choi, Ji-Yeon, et al. "Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation." Journal of Pharmacology and Experimental Therapeutics 344.2 (2013).
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PMID: 23197771 Applications: Western Blot Reactivity: Mouse
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Yefimova, Marina G. et al. “A Chimerical Phagocytosis Model Reveals the Recruitment by Sertoli Cells of Autophagy for the Degradation of Ingested Illegitimate Substrates.” Autophagy 9.5 (2013). |
PMCID: 3669177 Applications: Confocal Microscopy, Immunocytochemistry, Immunofluorescence, Western Blot Reactivity: Human
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Click Here for the complete list of all FabGennix Phospho-MerTK Antibody publications
Publishing research using PMKT-140AP? Please let us know, we can cite the reference in this datasheet.
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