Ephrin Receptor A3 Blocking Peptide

General Information

Product

Ephrin Receptor A3 Peptide

Description

Antigenic Blocking Peptide Ephrin Type-A Receptor 3 Antibody

Verified Applications

Immunocompetition, Immunodepletion

Peptide Description

Synthetic Peptide

Physical Properties

Quantity

250 µg

Volume

100 µl

Form

Antigenic Blocking Peptide

Storage

-20⁰C for long term storage

Application Protocol

Competition/Depletion assay

Refer to competition assay protocol

Protein

Uniprot #

P29320

Overview

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.

Molecular Function

ATP binding; Nucleotide binding

Subcellular Location

Isoform 1:  Cell membrane; Single-pass type I membrane protein.  Isoform 2:  Secreted

Expression

Widely expressed. Highest level in placenta.

Structure

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding.

Alternative Nomenclature

AW492086 antibody

Cek4 antibody

EC 2.7.10.1 antibody

EK4 antibody

End3 antibody

Eph receptor A3 antibody

EPH-like kinase 4 antibody

EPH-like tyrosine kinase 1 antibody

EphA3 antibody

Ephrin type-A receptor 3 antibody

ETK 1 antibody

ETK antibody

HEK 4 antibody

HEK antibody

Human embryo kinase 1 antibody

Mek4 antibody

MGC109882 antibody

Receptor tyrosine kinase HEK antibody

Tyro 4 antibody

Tyrosine-protein kinase TYRO4 antibody