General Information
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Product
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MRAP2 Peptide
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Description
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Antigenic Blocking Peptide Melanocortin-2 receptor accessory protein C-epitope
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic peptide taken within amino acid region 70-120 on mouse Melanocortin-2 receptor accessory protein.
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Accession #
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NCBI: AY079153
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Determinant
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C-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q9D159
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Overview
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Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells (By similarity).
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Molecular Function
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Brown fat cell differentiation; Positive regulation of cAMP biosynthetic process; Protein localization to cell surface
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Subcellular Location
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Single-pass membrane protein; Endoplasmic Reticulum membrane
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Expression
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Largely restricted to fat tissues. Predominantly expressed in mouse epididymal (white adipose tissue) and interscapular (brown adipose tissue) fat pads. Expression is weak or absent in lung, spleen, intestine, kidney, heart and skeletal muscle.
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Structure
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Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP2. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R (By similarity).
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Alternative Nomenclature
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bA51G5.2 antibody
BMIQ18 antibody
C6orf117 antibody
MC2R accessory protein 2 antibody
Melanocortin-2 receptor accessory protein 2 antibody
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