General Information

Product

SorLA Antibody

Description

Affinity Purified Sortilin-related receptor Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 2100-2200 on human SORLA receptor protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O88307

Overview

Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization, as well as the establishment of embryonic organ systems.

Molecular Function

beta-amyloid binding, low-density lipoprotein particle binding

Subcellular Location

membrane, single-pass type I membrane protein, golgi apparatus, secreted

Expression

Abundant in brain, where it is mainly expressed in adult cerebellum, hippocampal ca regions, dentate gyrus, and to a much lesser extent in the cerebral cortex. Detectable in kidney, skeletal muscle, lung and spleen, but not in the liver.

Alternative Nomenclature

C11orf32 antibody

gp250 antibody

LDLR relative with 11 ligand binding repeats antibody

Low-density lipoprotein receptor relative with 11 ligand-binding repeats antibody

LR11 antibody

LRP9 antibody

Mosaic protein LR11 antibody

SORL1 antibody

SorLA 1 antibody

Sortilin related receptor antibody

Sorting protein related receptor containing LDLR class A repeats antibody

Sorting protein-related receptor containing

General Information

Product

ENPP2 Antibody

Description

Affinity Purified ectonucleotide pyrophosphatase/phosphodiesterase 2 (Autotaxin) Antibody C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 778-818 on human Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) protein.

Accession #

GenBank: EAW91988.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:250

Protein

Uniprot #

UPI0000EE3297

Overview

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

Molecular Function

alkylglycerophosphoethanolamine phosphodiesterase activity; calcium ion binding; hydrolase activity; lysophospholipase activity; nucleic acid binding; nucleotide diphosphatase activity; phosphodiesterase I activity; polysaccharide binding; scavenger receptor activity; transcription factor binding; zinc ion binding

Subcellular Location

Secreted

Expression

Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.

Structure

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Contains 2 SMB (somatomedin-B) domains.

Alternative Nomenclature

ATX antibody

ATX X antibody

Autotaxin antibody

Autotaxin t antibody

Ectonucleotide pyrophosphatase/phosphodiesterase 2 antibody

Enpp2 antibody

Extracellular lysophospholipase D antibody

FLJ26803 antibody

LysoPLD antibody

NPP2 antibody

PD IALPHA antibody

PDNP2 antibody

Phosphodiesterase I alpha antibody

Plasma lysophospholipase D antibody

General Information

Product

AMACR Antibody

Description

Affinity Purified Alpha-methylacyl-CoA racemase isoform 1 Antibody N-epitope

Verified Applications

CM, DB, ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 50-100 on human alpha-methylacyl-CoA racemase protein.

Accession #

NCBI:  NP_055139

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:200

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9UHK6

Overview

Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.

Molecular Function

alpha-methylacyl-CoA racemase activity; receptor binding; bile acid metabolic process

Subcellular Location

Cytoplasm; Peroxisome; Mitochondrion

Alternative Nomenclature

2 arylpropionyl CoA epimerase antibody

2 methylacyl CoA racemase antibody

Alpha methylacyl CoA racemase antibody

Alpha methylacyl Coenzyme A racemase antibody

AMACR deficiency, included antibody

CBAS4 antibody

Da1-8 antibody

EC 5.1.99.4 antibody

Macr1 antibody

Methylacyl CoA racemase alpha antibody

P504S antibody

RACE antibody

RM antibody

General Information

Product

AMACR Antibody 

Description

Affinity Purified alpha-methylacyl-CoA racemase isoform 1 Antibody C-epitope

Verified Applications

CM, DB, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 260-310 on human alpha-methylacyl-CoA racemase protein.

Accession #

NCBI:  NP_055139

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DOT Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:200

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9UHK6

Overview

Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.

Molecular Function

alpha-methylacyl-CoA racemase activity; receptor binding; bile acid metabolic process

Subcellular Location

Cytoplasm; Peroxisome; Mitochondrion

Alternative Nomenclature

2 arylpropionyl CoA epimerase antibody

2 methylacyl CoA racemase antibody

Alpha methylacyl CoA racemase antibody

Alpha methylacyl Coenzyme A racemase antibody

AMACR deficiency, included antibody

CBAS4 antibody

Da1-8 antibody

EC 5.1.99.4 antibody

Macr1 antibody

Methylacyl CoA racemase alpha antibody

P504S antibody

RACE antibody

RM antibody

General Information

Product

Phospholipase A2 Antibody

Description

Affinity Purified Phospholipase A2-activating protein Antibody C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 450-500 on human Phospholipase A2-activating protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q9Y263

Overview

Involved in the maintenance of ubiquitin levels.

Molecular Function

Phospholipase A2 activator activity; Inflammatory response; Phospholipid metabolic process; Signal transduction

Subcellular Location

Extracellular vesicular exosome

Structure

Interacts with ubiquitin. Interacts with VCP.

Alternative Nomenclature

Calcium dependent phospholipid binding protein antibody

CPLA 2 antibody

Cytosolic phospholipase A2 antibody

Cytosolic phospholipase A2 group IVA antibody

Lysophospholipase antibody

MGC126350 antibody

Phosphatidylcholine 2 acylhydrolase antibody

Phospholipase A2 group 4 A antibody

Phospholipase A2 group IVA antibody

PhospholipaseA2 antibody

PLA2G4 antibody

General Information

Product

Phospholipase A2 Antibody 

Description

Affinity Purified Phospholipase A2-activating protein Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Rat, Mouse, Human, Monkey, Bovine

Immunogen

Synthetic peptide taken within amino acid region 30-80 on human Phospholipase A2-activating protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q9Y263

Overview

Involved in the maintenance of ubiquitin levels.

Molecular Function

Phospholipase A2 activator activity; Inflammatory response; Phospholipid metabolic process; Signal transduction

Subcellular Location

Extracellular vesicular exosome

Structure

Interacts with ubiquitin. Interacts with VCP.

Alternative Nomenclature

Calcium dependent phospholipid binding protein antibody

CPLA 2 antibody

Cytosolic phospholipase A2 antibody

Cytosolic phospholipase A2 group IVA antibody

Lysophospholipase antibody

MGC126350 antibody

Phosphatidylcholine 2 acylhydrolase antibody

Phospholipase A2 group 4 A antibody

Phospholipase A2 group IVA antibody

PhospholipaseA2 antibody

PLA2G4 antibody

General Information

Product

Phospho PDE3B Antibody

Description

Affinity Purified Phosphorylated Phosphodiesterase 3B Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 260-310 on rat PDE3B protein. Selective for only PDE3B variant

Accession #

NCBI:  EDM17772.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

1.0-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

UPI000154F033

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3.

Molecular Function

Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding

Subcellular Location

Membrane; Multipass membrane protein

Expression

Abundant in adipose tissues.

Structure

Interacts with PIK3CG. Interacts with RAPGEF3 and PIK3R6 (By similarity).

Alternative Nomenclature

5''-cyclic phosphodiesterase B antibody

Adipocyte cAMP phosphodiesterase cGMP inhibited antibody

AI847709 antibody

cAMP Phosphodiesterase, adipocyte, cGMP-inhibited antibody

CGI-PDE B antibody

CGIP1 antibody

CGIPDE1 antibody

cGMP inhibited 3 5 cyclic phosphodiesterase B antibody

HcGIP1 antibody

Pde3b antibody

Phosphodiesterase 3B cGMP inhibited antibody

General Information

Product

Phospho PDE3B Antibody Affinity Purified

Description

Affinity Purified Phosphorylated Phosphodiesterase 3B Antibody C-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 260-310 on human PDE3B protein. Selective only for PDE3B variant.

Accession #

GenBank:  BAA09306

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q13370

Overview

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3.

Molecular Function

Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding

Subcellular Location

Membrane; Multipass membrane protein

Expression

Abundant in adipose tissues.

Structure

Interacts with PIK3CG. Interacts with RAPGEF3 and PIK3R6 (By similarity).

Alternative Nomenclature

5''-cyclic phosphodiesterase B antibody

adipocyte cAMP phosphodiesterase cGMP inhibited antibody

AI847709 antibody

cAMP Phosphodiesterase, adipocyte, cGMP-inhibited antibody

CGIP1 antibody

CGIPDE B antibody

cGMP inhibited 3 5 cyclic phosphodiesterase B antibody

CGMP inhibited cAMP phophodiesterase antibody

cGMP-inhibited 3'' antibody

Cyclic GMP-inhibited phosphodiesterase B antibody

Cyclic nucleotide phosphodiesterase antibody

HcGIP1 antibody

Phosphodiesterase 3B cGMP inhibited antibody

General Information

Product

ELOVL4 Antibody

Description

Affinity Purified Elongation of very long chain fatty acids protein 4 Antibody

N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Cat, Rat

Immunogen

Synthetic peptide corresponding to amino acids 2-22 of Human ELOVL4 protein.

Sequence:

GLLDSEPGSVLNVVSTALNDT

Accession #

NCBI:  NP_073563

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q9GZR5

Overview

Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor-specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development.

Molecular Function

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Subcellular Location

Endoplasmic Reticulum; Membrane

Expression

Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no expression in heart, lung, liver, or leukocates.

Structure

The di-lysine motif may confer endoplasmic reticulum localization.

Alternative Nomenclature

3-keto acyl-CoA synthase ELOVL4 antibody

ADMD antibody

Cancer/testis antigen 118 antibody

CT118 antibody

Elongation of very long chain fatty acids (FEN1/Elo2 SUR4/Elo3 yeast) like 4 antibody

ELOV L4 antibody

Stargardt disease 3 antibody

STGD2 antibody

STGD3 antibody

General Information

Product

GPCR GPR120 Antibody

Description

Affinity Purified Free fatty acid receptor A4 Antibody C-epitope

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

C-epitope synthetic peptide taken within amino acid region 220-300 on human FFAR4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58-0.59 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q5NUL3

Overview

Functions as a receptor for medium and long chain free fatty acids,signals through a G(q)/G(11)-coupled pathway.  Functions as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects.

Molecular Function

G-protein coupled receptor, Transducer, Receptor, Fatty acid binding

Subcellular Location

Cell membrane; Multipass membrane protein

Expression

Expression in intestinal tract with high expression in adipose tissue, small intestine and pancreas

Structure

Interacts with ARRB2 subsequent to docosahexaenoic acid stimulation

Alternative Nomenclature

G protein coupled receptor 120 antibody

G protein coupled receptor 129 antibody

G protein coupled receptor GT01 antibody

G protein coupled receptor PGR4 antibody

GPR 120 antibody

GPR 129 antibody

GT01 antibody

HGNC:19345 antibody

MGC119984 antibody

O3FAR1 antibody

Omega-3 fatty acid receptor 1 antibody

PGR 4 antibody