General Information |
|
Product |
AMPK alpha 2 Antibody BIOTIN |
Description |
BIOTIN-Conjugated 5'-AMP-activated protein kinase catalytic subunit alpha-2 Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 480-530 on rat 5'-AMP-activated protein kinase catalytic subunit alpha-2 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
BIOTIN-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:50,000 |
Immunohistohemistry | 1:50-1:250 |
Immunoprecipitation |
1:200 |
Western Blot |
1:2,500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. |
Molecular Function |
[acetyl-CoA carboxylase] kinase activity [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity AMP-activated protein kinase activity ATP binding Source: RGD chromatin binding histone serine kinase activity metal ion binding -KW protein binding |
Subcellular Location |
Nucleus, Cytoplasm |
Expression |
Skeletal muscle, lower levels in liver, heart and kidney. |
Structure |
The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity. |
Alternative Nomenclature |
5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody ACACA kinase antibody Acetyl-CoA carboxylase kinase antibody AMPK alpha 2 chain antibody AMPK subunit alpha-2 antibody AMPK2 antibody AMPKa2 antibody HMGCR kinase antibody Hydroxymethylglutaryl-CoA reductase kinase antibody PRKAA antibody PRKAA2 antibody Protein kinase AMP activated alpha 2 catalytic subunit antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
AMPK2-201AP | |||
|
AMPK2-FITC | |||
|
P-AMPK2 | |||
|
PC-AMPK2 | |||
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