Western Blot Positive ControlNAD-dependent protein deacetylase sirtuin-1 isoform 1 Antibody
Verified Applications
WB
Accession #
NCBI: NP_062786.1
Physical Properties
Quantity
5 Applications
Volume
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Concentration
The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel.
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autphagy.
Subcellular Location
Nucleus, PML body, cytoplasm. (Nucleus: Recruited to the nuclear bodies via its interaction with the PML. Colocalized with APEX1 in nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm).
Expression
Widely expressed. Weakly expressed in liver and skeletal muscle.