General Information

Product

Neurochondrin Antibody 

Description

NORBIN Antibody

Verified Applications

ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on rat NORBIN protein.

Accession #

GenBank: BAA22938.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1;10,000

ELISA

1;10,000

Western Blot

1:500

Protein

Uniprot #

O35095

Overview

Involved in regulation of neuronal synaptic plasticity;neuron projection development;bone resorption

Subcellular Location

Cell projection, Cytoplasm,somatic regions of neurons

Expression

Expressed in brain and in peripheral nervous system (at protein level). Weakly expressed in neurites.

Structure

Belongs to the neurochondrin family.

Alternative Nomenclature

AU042419 antibody

KIAA0607 antibody

M-Sema F-associating protein of 75 kDa antibody

MGC93259 antibody

MMS10-AE antibody

NCDN antibody

NCDN-1 antibody

NCDN-2 antibody

Neurochondrin 1 antibody

Norbin antibody

Sfap75 antibody

General Information

Product

Niemann Pick C1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1228-1278 on human Niemann-Pick C1 protein.

Accession #

NCBI:  NP_000262.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:4,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

O15118

Overview

Intracellular cholesterol transporter plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment.

Molecular Function

Receptor activity

Subcellular Location

Endosome, Lysosome, Membrane

Expression

Adrenal gland; Cerebral cortex; lung; placenta; lymph node

Structure

Belongs to the patched family.

Alternative Nomenclature

Niemann Pick C1 antibody

Niemann Pick C1 protein precursor antibody

Niemann Pick disease, type C1 antibody

NPC antibody

NPC1 antibody

General Information

Product

NPY2R Antibody

Description

Affinity Purified Neuropeptide Y receptor Y2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-381 on human NPY2R protein.

Accession #

GenBank: AAO92062.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P49146

Overview

Receptor for neuropeptide Y and peptide YY

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Cell membrane, Membrane

Expression

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.

Structure

Belongs to the G-protein coupled receptor 1 family

Alternative Nomenclature

Neuropeptide Y Receptor Type 2 antibody

NPY2R antibody

NPYY2 Receptor antibody

Y2 receptor antibody

General Information

Product

Nurr1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide corresponding to amino acid region 566-591. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using hetero bifunctional cross linker. 

Sequence:

CTQGLQRIFYLKLEDLVPPPAIIDKL

Accession #

GenBank: BAA75666.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P43354

Overview

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development.

Molecular Function

Receptor

Subcellular Location

Cytoplasm, Nucleus

Expression

Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue.

Structure

Belongs to the nuclear hormone receptor family. NR4 subfamily.

Alternative Nomenclature

HZF 3 antibody

Immediate-early response protein NOT antibody

NGFI B/nur77 beta type transcription factor homolog antibody

NOT antibody

NR4A2 antibody

Nur related protein 1 homolog antibody

Nurr 1 antibody

Orphan nuclear receptor NR4A2 antibody

RNR1 antibody

T cell nuclear receptor NOT antibody

TINUR antibody

Transcriptionally inducible nuclear receptor antibody

General Information

Product

P2Y12 Antibody

Description

P2Y purinoceptor 12 Antibody

Verified Applications

Cell labeling, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chimpanzee, Human, Monkey, Porcine, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-342 on human P2Y12 protein.

Accession #

NCBI:  NP_795345.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57-0.68 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9H224

Overview

Serves as a receptor for ADP and ATP that is coupled to G-proteins that inhibit the adenylyl cyclase second messenger system.  It is necessary for platelet aggregation and blood coagulation.

Molecular Function

G-protein coupled receptor, Transducer, ADP-receptor activity

Subcellular Location

Cell membrane; Multipass membrane protein

Expression

It is highly expressed in the platelets with lower levels of expression found in the brain, and is also expressed in the spinal cord and fetal brain.  The lowest levels of expression are found in the lung, appendix, pituitary and adrenal gland.

Alternative Nomenclature

ADP glucose receptor antibody

ADPG R antibody

ADPGR antibody

BDPLT8 antibody

G protein coupled receptor SP1999 antibody

Gi coupled ADP receptor HORK 3 antibody

HORK 3 antibody

P2RY 12 antibody

P2T(AC) antibody

P2Y 12 antibody

P2Y purinoceptor 12 antibody

P2Y(ADP) antibody

P2Y(cyc) antibody

P2Y12 antibody

P2Y12 platelet ADP receptor antibody

Platelet ADP receptor antibody

Purinergic receptor P2RY12 antibody

Purinergic receptor P2Y G protein coupled 12 antibody

Purinergic receptor P2Y12 antibody

Putative G protein coupled receptor antibody

SP 1999 antibody

General Information

Product

P2Y1 Antibody

Description

Affinity Purified P2Y purinoceptor 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 360-410 on rat P2Y1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.85 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P49651

Overview

Serves as a receptor for extracellular adenine nucleotides, for example ATP and ADP.  It may mediate some effects of extracellular ATP on insulin secretion in the pancreatic islets.

Molecular Function

G-protein coupled receptor, Transducer, Receptor

Subcellular Location

Cell membrane; Multipass membrane protein

Expression

Is found to be expressed in muscle, heart, liver, kidney, lung, brain, spleen.  Not expressed in testis.

Alternative Nomenclature

ATP receptor antibody

P2 purinoceptor subtype Y1 antibody

P2RY1 antibody

P2RY1_HUMAN antibody

P2Y purinoceptor 1 antibody

P2Y1 antibody

P2Y1 purinoceptor antibody

Platelet ADP receptor antibody

Purinergic receptor antibody

Purinergic receptor P2Y G protein coupled 1 antibody

Purinergic receptor P2Y1 antibody

General Information

Product

P2Y2 Antibody

Description

Affinity Purified P2Y purinoceptor 2 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 360-410 on rat P2Y2 protein.

Accession #

GenBank: EAW74883.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.68 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

A0A024R5N1

Overview

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

Molecular Function

G-protein coupled receptor, Receptor, Transducer

Subcellular Location

Membrane

Expression

Spleen, testis, kidney, liver, lung, heart and brain.

Structure

Belongs to the G-protein coupled receptor 1 family.

Alternative Nomenclature

ATP receptor antibody

HP2U antibody

Human P2U nucleotide receptor mRNA complete cds antibody

MGC20088 antibody

MGC40010 antibody

P2RU1 antibody

P2RY2 antibody

P2U antibody

P2U nucleotide receptor antibody

P2U purinoceptor 1 antibody

P2U receptor 1 antibody

P2U1 antibody

P2UR antibody

P2Y purinoceptor 2 antibody

P2Y2 antibody

P2Y2R antibody

Purinergic receptor antibody

Purinergic receptor P2Y G protein coupled 2 antibody

Purinergic receptor P2Y2 antibody

Purinoceptor P2Y2 antibody

General Information

Product

Pannexin 1 Antibody

Description

Affinity Purified ECEL1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region from human Pannexin 1  protein

Accession #

GenBank: AAQ89282.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O95672

Overview

May play a role in the degradation of peptide hormones.  It also may contribute to the inactivation of neuronal peptides.

Subcellular Location

Membrane; Single-pass type II membrane protein

Alternative Nomenclature

innexin antibody

MRS1 antibody

Pannexin 1 antibody

Panx1 antibody

UNQ2529 antibody

General Information

Product

Phospho-CACNB2 Antibody

Description

Affinity Purified Voltage dependent L-type calcium channel subunit beta-2 Antibody

Verified Applications

Cell labeling, ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 600-655 on rat CACNB2 protein.

Accession #

NCBI: NP_446303

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8VGC3

Overview

The beta subunit of voltage-dependent calcium channel which contributes to calcium channel function by increasing peak calcium current, shifting the voltage dependencies fo activation and inactivation, modulating G-protein inhibition and controllin the alpha-1 subunit membrane targeting.

Molecular Function

Calcium; Transport; Ion transport

Subcellular Location

Cell membrane; Sacrolemma; Peripheral membrane protein, cytoplasmic side

Expression

Heart and brain.  Lower expression in lung.

Structure

L-type channel is composed of four subunits:  alpha-1, alpha-2, beta and gamma.

Alternative Nomenclature

AW060387 antibody

Ca(V) beta 2 antibody

CAB2 antibody

CAVB2 antibody

Cavbeta2 antibody

Cchb2 antibody

Lambert Eaton Myasthenic syndrome antigen antibody

MYSB antibody

General Information

Product

Phospho Ephrin receptor A4 Antibody Affinity Purified

Description

Affinity Purified Phosphorylated Ephrin type-A receptor 4 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 570-630 on human EPHA R4 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q03137

Overview

Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.

Molecular Function

ATP-binding, Nucleotide-binding

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Highest expression in the adult brain and retina and also detectable in kidney, lung, skeletal muscle and thymus. Not detected in heart and liver.

Structure

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (phosphorylated at position Tyr-602) with FYN. Interacts (via

Alternative Nomenclature

Cek 8 antibody

EK8 antibody

eph receptor a4 antibody

EPH-like kinase 8 antibody

EphA4 antibody

Ephrin receptor Eph A4 antibody

hEK8 antibody

Receptor protein tyrosine kinase HEK 8 antibody

Sek 1 antibody

SEK antibody

TYRO 1 protein tyrosine kinase antibody

Tyrosine protein kinase receptor SEK antibody