General Information
|
|
Product
|
ASIC2 Peptide
|
Description
|
Antigenic Blocking Peptide Acid-sensing ion channel 2 Antibody
|
Verified Applications
|
Immunodepletion, Immunocompetition
|
Peptide Description
|
Synthetic peptide taken within amino acid region 450-512 on human Acid-sensing ion channel 2 protein.
|
Physical Properties
|
|
Quantity
|
250 µg
|
Volume
|
100 µl
|
Form
|
Antigenic Blocking Peptide
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Competition/Depletion assay
|
Refer to competition assay protocol
|
Protein
|
Uniprot #
|
Q16515
|
Overview
|
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li+ and K+. Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
|
Molecular Function
|
acid-sensing ion channel activity; ion gated channel activity; ligand-gated sodium channel activity
|
Subcellular Location
|
Cell membrane; Multi-pass membrane protein
|
Expression
|
Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
|
Structure
|
Homotrimer or heterotrimer with other ASIC proteins.
|
Alternative Nomenclature
|
ACCN1 antibody
Acid sensing ion channel 2 antibody
Amiloride sensitive brain sodium channel antibody
Amiloride sensitive cation channel 1 neuronal antibody
ASIC2 antibody
BNaC1 antibody
Brain sodium channel 1 antibody
Degenerin antibody
Mammalian degenerin homolog antibody
MDEG antibody
Neuronal amiloride sensitive cation channel 1 antibody
|
|
|