General Information |
|
Product |
TSG101 Antibody BIOTIN |
Description |
BIOTIN-Conjugated Tumor susceptibility gene 101 protein Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 330-390 on Tumor susceptibility gene 101 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
BIOTIN-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunocytochemistry |
1:50-1:150 |
Immunohistochemistry |
1:50-1:150 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). |
Molecular Function |
calcium-dependent protein binding DNA binding ligand-dependent nuclear receptor transcription coactivator activity protein homodimerization activity transcription corepressor activity ubiquitin binding ubiquitin protein ligase binding virion binding |
Subcellular Location |
Cytoplasm Membrane; Peripheral membrane protein Nucleus Late endosome membrane; Peripheral membrane protein |
Expression |
Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas. |
Alternative Nomenclature |
ESCRT I complex subunit TSG101 antibody TS101_HUMAN antibody TSG 10 antibody TSG 101 antibody Tumor susceptibility gene 10 antibody Tumor susceptibility gene 101 antibody Tumor susceptibility protein antibody Tumor susceptibility protein isoform 3 antibody VPS23 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
TSG101-101AP | |||
|
TSG101-FITC | |||
|
P-TSG101 | |||
|
PC-TSG101 | |||
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