General Information |
|
Product |
ErbB 2 Antibody FITC-Conjugated |
Description |
FITC-Conjugated Receptor tyrosine-protein kinase erB-2 isoform a Antibody N-epitope |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse Predicted: Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1125-1175 receptor tyrosine-protein kinase erbB-2 protein. |
Accession # |
NCBI: NP_004439.2 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.65-1.25 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Determinant |
N-epitope |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). |
Molecular Function |
Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus. |
Expression |
Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. |
Structure |
Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG). |
Alternative Nomenclature |
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody CD340 antibody CerbB2 antibody cneu antibody Erb B2 antibody erbb2 antibody Erythroblastosis Virus antibody HER 2 antibody Herstatin antibody Metastatic lymph node gene 19 protein antibody MLN 19 antibody NEU antibody Neuro Glioblastoma Derived Oncogene Homolog antibody NGL antibody p185 ErbB2 antibody Proto-oncogene Neu antibody Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody Tyrosine kinase-type cell surface receptor HER2 antibody V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
ERB2-201AP | |||
|
ERB2-BIOTIN | |||
|
P-ERB2 | |||
|
PC-HER2 | |||
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