General Information |
|
Product |
Presenilin 2 Peptide |
Description |
Antigenic Blocking Peptide Presenilin-2 isoform 1 Antibody N-epitope |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic Peptide |
Accession # |
NCBI: NP_036618 |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Determinant |
N-epitope |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
|
|
|
Uniprot # |
|
Overview |
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. |
Molecular Function |
Hydrolase, Protease, aspartic-type endopeptidase activity |
Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
Expression |
Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. |
Structure |
Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase a |
Alternative Nomenclature |
AD 3LP antibody AD 4 antibody AD 5 antibody Alzheimer disease 4 antibody CMD1V antibody E5 1 antibody Presenilin 2 (Alzheimer disease 4) antibody PS2 antibody PSEN 2 antibody STM2 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
PSEN-201AP | |||
|
PSEN2-FITC | |||
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PSEN2-BIOTIN | |||
|
PC-PSEN2 | |||
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