General Information |
|
Product |
MeCP2 isoform 1 Antibody FITC |
Description |
FITC-Conjugated Methyl-CpG-binding protein 2 Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1-50 on mouse methyl-CpG-binding protein 2 isoform 1. |
Accession # |
NCBI: NP_004983 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:50,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:2,500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). |
Molecular Function |
Chromatin binding, DNA binding, mRNA binding, double-stranded methylated DNA binding, poly(A) RNA binding, siRNA binding |
Subcellular Location |
Nucleus (Note: Colocalized with methyl-CpG in the genome) |
Expression |
Interacts with FNBP3. Interacts with CDKL5 (PubMed:15917271). Interacts with ATRX; MECP2 recruits ATRX to pericentric heterochromatin in neuronal cells. Interacts with NCOR2. |
Structure |
Present in all adult somatic tissues tested. |
Alternative Nomenclature |
AUTSX 3 antibody Mbd5 antibody MeCP-2 protein antibody MeCP2 antibody Methyl CpG binding protein 2 (Rett syndrome) antibody Methyl CpG binding protein 2 antibody MRX 16 antibody MRX 79 antibody MRXS13 antibody MRXSL antibody PPMX antibody RS antibody RTS antibody RTT antibody WBP 10 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
MECP2E1-101AP | |||
|
MECP2E1-BIOTIN | |||
|
P-MECP2E1 | |||
|
PC-MECP2E1 | |||
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