General Information |
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Product |
Aurora A Antibody Peptide |
Description |
Antigenic Blocking Peptide Aurora Kinase A |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 350-397 on human Aurora Kinase A protein. |
Accession # |
NCBI: NP_695208 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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|
Western Blot |
1:2,500-1:5,000 |
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Uniprot # |
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Overview |
Mitotic serine/threonine kinases that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. |
Molecular Function |
ATP binding histone serine kinase activity protein heterodimerization activity protein kinase activity protein kinase binding protein serine/threonine/tyrosine kinase activity protein serine/threonine kinase activity ubiquitin protein ligase binding |
Subcellular Location |
centrosome spindle pole cilium basal body centriole |
Expression |
Detected in embryonic neurons in dorsal root ganglia and brain cortex (at protein level). Highly expressed in testis, in about one third of the seminiferous tubules. Expression is restricted to specific spermatocytes nearing completion of prophase, with levels falling off on transition to elongated spermatids. Highly expressed in the ovary, expression in the oocyte starts around the transition to large growing follicle. Abundant expression is seen in the proliferating granulosa and thecal cells of the growing follicle, and in the young corpus luteum. Very weakly expressed in spleen and intestine. |
Structure |
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. |
Alternative Nomenclature |
AIK antibody ARK1 antibody AURA antibody Aurora 2 antibody Aurora A antibody Aurora kinase A antibody Aurora-related kinase 1 antibody Aurora/IPL1 like kinase antibody AURORA2 antibody Breast tumor-amplified kinase antibody BTAK antibody hARK1 antibody IAK antibody IPL1 related kinase antibody PPP1R47 antibody Protein phosphatase 1, regulatory subunit 47 antibody Serine/threonine kinase 15 antibody Serine/threonine kinase 6 antibody Serine/threonine-protein kinase aurora-A antibody STK15 antibody STK6 antibody STK7 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
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AURKA-101AP | |||
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AURKA-BIOTIN | |||
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AURKA-FITC | |||
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PC-AURKA | |||
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