General Information
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Product
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ITPR2 Antibody BIOTIN-Conjugated
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Description
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BIOTIN-Conjugated Inositol 1,4,5-triphosphate receptor type 2 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 100-150 on rat Inosital 1,4,5-triphosphate receptor type 2 protein.
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Accession #
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NCBI: NP_112308
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.66 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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BIOTIN-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunohistochemistry |
1:50-1:100 |
Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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P29995
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Overview
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Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.
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Molecular Function
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Calcium ion binding; inositol 1,4,5-triphosphate binding; cellular response to hypoxia; Transport
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Subcellular Location
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Endoplasmic reticulum membrane; Multi-pass membrane protein
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Expression
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Isoform Short is found in skeletal muscle and heart.
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Structure
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The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
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Alternative Nomenclature
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4 antibody
5-trisphosphate receptor antibody
Inositol 1 4 5 trisphosphate receptor type 2 antibody
InsP3R2 antibody
IP3 R2 antibody
IP3 receptor antibody
IP3 receptor isoform 2 antibody
IP3R 2 antibody
ITPR 2 antibody
Type 2 inositol 1 4 5 trisphosphate receptor antibody
Type 2 inositol 1 antibody
Type 2 InsP3 receptor antibody
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