General Information |
|
Product |
HMGB1 Antibody FITC-Conjugated |
Description |
FITC-Conjugated High mobility group protein B1 Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 150-200 on human High mobility group protein B1 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:50,000 |
Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation |
1:200 |
Western Blot |
1:2,500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. |
Molecular Function |
bubble DNA binding chemoattractant activity C-X-C chemokine binding cytokine activity damaged DNA binding DNA binding, bending DNA binding transcription factor activity DNA polymerase binding double-stranded DNA binding four-way junction DNA binding integrin binding lipopolysaccharide binding lyase activity phosphatidylserine binding RAGE receptor binding repressing transcription factor binding RNA binding single-stranded DNA binding supercoiled DNA binding transcription factor binding |
Subcellular Location |
Extracellular region or secreted, nucleus, endosome, plasma membrane, chromosome, cytoplasm, endoplasmic reticulum-golgi intermediate compartment |
Expression |
Ubiquituous. Expressed in platelets. |
Structure |
Belongs to the HMGB family. |
Alternative Nomenclature |
Amphoterin antibody Chromosomal protein, nonhistone, HMG1 antibody High mobility group box 1 antibody High mobility group protein 1 antibody High mobility group protein B1 antibody high-mobility group (nonhistone chromosomal) protein 1 antibody HMG-1 antibody HMG3 antibody HMGB 1 antibody NONHISTONE CHROMOSOMAL PROTEIN HMG1 antibody SBP 1 antibody Sulfoglucuronyl carbohydrate binding protein antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
HMGB1-101AP | |||
|
HMGB1-BIOTIN | |||
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P-HMGB1 | |||
|
PC-HMGB1 | |||
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