General Information

Product

EpCAM Antibody

Description

Affinity Purified Tumor-associated Calcium signal transducer 1 Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

N-epitope specific synthetic peptide taken within amino acid region 100-200 on human Tumor-associated calcium signal transducer 1 protein.

Accession #

GenBank: EAX00219.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.78 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

UPI0000EE24A7

Overview

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

Molecular Function

Tumor antigen

Subcellular Location

Cell junction, Cell membrane, Membrane, Tight junction

Expression

Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.

Structure

Belongs to EPCAM family.  Contains 1 thryoglobulin type-1 domain.

Alternative Nomenclature

17 1A antibody

323/A3 antibody

Adenocarcinoma associated antigen antibody

Antigen identified by monoclonal antibody AUA1 antibody

CD326 antibody

Cell surface glycoprotein Trop 1 antibody

Cell surface glycoprotein Trop 2 antibody

CO17 1A antibody

DIAR5 antibody

EGP antibody

EGP2 antibody

EGP314 antibody

EGP40 antibody

Ep CAM antibody

Epithelial cell adhesion molecule antibody

Epithelial glycoprotein 314 antibody

ESA antibody

GA733 1 antibody

gastrointestinal tumor-associated antigen 2, 35-KD glycoprotein antibody

HNPCC8 antibody

Human epithelial glycoprotein 2 antibody

KS 1/4 antigen antibody

KSA antibody

Lymphocyte antigen 74 antibody

M1S 1 antibody

M1S2 antibody

M4S1 antibody

Major gastrointestinal tumor associated protein GA733 2 antibody

Membrane component chromosome 4 surface marker (35kD glycoprotein) antibody

MIC18 antibody

MK 1 antibody

TACD1 antibody

TROP1 antibody

Tumor associated calcium signal transducer 1 antibody

Tumor associated calcium signal transducer 2 precursor antibody

General Information

Product

XTP4 Antibody Affinity Purified

Description

Affinity Purified Chromosome17 orf 37 Antibody Multiple Epitope

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Multiple epitope synthetic peptide taken within amino acid regions 1-50, 20-70, 40-90 and 80-130 on human XTP4 protein.

Accession #

GenBank: AF490253.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.83 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Multiple Epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:2,000

ELISA

1:2,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q9BRT3

Overview

Increases cell migration by induction of filopodia formation at leading edge.  Regulates apoptosis and redox-related process.

Molecular Function

Apoptosis

Subcellular Location

Cytoplasm; Cytosol; Cell membrane; Lipid anchor

Expression

Present in Leydig cells.  Up-regulated in breast cancers and brain cancer distant metastasis also up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma.

Structure

Belongs to SelWTH family

Alternative Nomenclature

C17orf37 antibody

C17orf37 homolog antibody

C35 antibody

chromosome 17 open reading frame 37 antibody

HBV X transactivated gene 4 protein antibody

HBV XAg transactivated protein 4 antibody

MGC14832 antibody

Mien1 antibody

Migration and invasion enhancer 1 antibody

ORB3 antibody

Protein C17orf37 antibody

Protein C35 antibody

RDX12 antibody

Redox protein, 12-KD antibody

XTP4 antibody

General Information

Product

PD-L1 Antibody

Description

Affinity Purified Programmed cell death 1 ligand 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Predicted: Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid reigon 80-130 on human Progammed cell death 1 ligand 1 protein.

Accession #

NCBI:  NP_054862

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q9NZQ7

Overview

Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

Molecular Function

Receptor

Subcellular Location

Isoform 1 : Cell membrane; Single-pass type I membrane protein

Isoform 2 : Endomembrane system; Single-pass type I membrane protein

Expression

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Structure

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative Nomenclature

B7 H antibody

B7 homolog 1 antibody

CD 274 antibody

PD L1 antibody

PDCD1 ligand 1 antibody

PDCD1L1 antibody

PDCD1LG1 antibody

PDL 1 antibody

Programmed death ligand 1 antibody

RGD1566211 antibody

General Information

Product

FOLR1 Antibody

Description

Affinity Purified Folate receptor Alpha Antibody

Verified Applications

ELISA, ICC/IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on mouse Folate receptor alpha protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P35846

Overview

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.

Molecular Function

Receptor

Subcellular Location

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane, Secreted

Expression

Detected in kidney proximal tubules.

Structure

Belongs to the folate receptor family.

Alternative Nomenclature

adult antibody
Adult folate binding protein antibody
FBP antibody
Folate Receptor 1 Adult antibody
Folate receptor 1 antibody
Folate receptor alpha antibody
Folate receptor antibody
FOLR antibody
FOLR1 antibody
FR alpha antibody
KB cells FBP antibody
MOV18 antibody
Ovarian cancer associated antigen antibody
Ovarian tumor associated antigen MOv18 antibody