|
General Information
|
|
|
Product
|
KIRREL Antibody
|
|
Description
|
Affinity Purified Kin of IRRE-like protein 1 Antibody
|
|
Verified Applications
|
CM, ELISA, ICC, IF, IHC, IP, WB
|
|
Host
|
Rabbit
|
|
Species Cross Reactivity
|
Human, Mouse, Rat
|
|
Immunogen
|
Recombinant protein
|
|
Physical Properties
|
|
|
Quantity
|
100 µg
|
|
Volume
|
200 µl
|
|
Concentration
|
0.45-0.65 µg/µl in antibody stabilization buffer
|
|
Form
|
Affinity Purified
|
|
Clonality
|
Polyclonal
|
|
Storage
|
-20⁰C for long term storage
|
|
Application Protocol
|
|
Confocal Microscopy
|
1:250
|
|
DOT Blot
|
1:10,000
|
|
ELISA
|
1:10,000
|
|
Immunocytochemistry
|
1:250
|
|
Immunofluorescence
|
1:250
|
|
Immunohistochemistry
|
1:250
|
|
Immunoprecipitation
|
1:250
|
|
Western Blot
|
1:250
|
|
Protein
|
|
Uniprot #
|
Q80W68
|
|
Overview
|
Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.
|
|
Molecular Function
|
Myosin Binding
|
|
Subcellular Location
|
Cell membrane; Single-pass type I membrane protein
|
|
Expression
|
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.
|
|
Structure
|
Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylated with GRB2.
|
|
Alternative Nomenclature
|
FLJ10845 antibody
Kin of IRRE like (Drosophila) antibody
Kin of IRRE like antibody
Kin of irregular chiasm-like protein 1 antibody
Kirrel antibody
MGC129542 antibody
MGC129543 antibody
NEPH 1 antibody
Nephrin like protein 1 antibody
Nephrin related antibody
|
| |
|
KIRREL Antibody FITC
KIRREL Antibody BIOTIN
KIRREL Blocking Peptide
KIRREL Positive Control
