General Information |
|
Product |
Filamin B (phospho Ser 2478) Antibody FITC |
Description |
FITC-Conjugated Phospho-Filamin-B Antibody N-epitope |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse |
Immunogen |
Synthetic peptide taken within amino acid region 2450-2500 on human Phospho-Filamin-B. Phosphorylated 2478 serine residue. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Determinant |
N-epitope |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:50,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:2,500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. |
Molecular Function |
actin binding cadherin binding identical protein binding RNA binding |
Subcellular Location |
Cytoskeleton |
Expression |
Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart. |
Structure |
Homodimer. Interacts with MICALL2. Interacts with RFLNA and RFLNB. Isoform 1 interacts with FBLP1, FLNA, FLNC, GP1BA, INPPL1, ITGB1A, PSEN1 and PSEN2. Isoform 3 interacts with ITGB1A, ITGB1D, ITGB3 and ITGB6. |
Alternative Nomenclature |
ATPDase antibody CD 39 antibody Ecto apyrase antibody Ecto ATP diphosphohydrolase antibody Ecto-apyrase antibody Ecto-ATP diphosphohydrolase 1 antibody Ecto-ATPase 1 antibody Ecto-ATPDase 1 antibody Ectonucleoside triphosphate diphosphohydrolase 1 antibody ENTPD 1 antibody Lymphoid cell activation antigen antibody NTPDase 1 antibody SPG64 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
PFLNB-140AP | |||
|
PC-PFLNB | |||
|
P-PFLNB-140 | |||
|
PFLNB-140-BIOTIN | |||
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