General Information |
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Product |
Pan PDE1C Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Human 3',5' cyclic nucleotide phosphodiesterase (HSPDE1C1A) Antibody N-epitope |
Verified Applications |
CM, ELISA, ICC, IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene. |
Specificity | This antibody does not cross-react with PDE1A, PDE1B, or other PDE family members. This antibody will label all PDE1C variants including PDE1C1, PDE1C2, and PDE1C3. |
Accession # |
GenBank: U40371.1 |
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|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Determinant |
N-epitope |
Storage |
-20⁰C for long term storage |
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|
Confocal Microscopy |
1:40-1:100 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:40-1:100 |
Immunofluorescence |
1:100 |
Immunohistochemistry |
1:40-1:100 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500-1:2,000 |
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|
Uniprot # |
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Overview |
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. |
Molecular Function |
Hydrolase, calmodulin-dependent cyclic-nucleotide phosphodiesterase activity, metal ion binding |
Subcellular Location |
Cytosol |
Expression |
Expressed in several tissues, including brain and heart. |
Structure |
Homodimer |
Alternative Nomenclature |
5''-cyclic nucleotide phosphodiesterase 1C antibody Calcium/calmodulin dependent 3'5' cyclic nucleotide phosphodiesterase 1C antibody Cam PDE 1C antibody HCAM3 antibody HSPDE1C1A antibody Human 3'5' cyclic nucleotide Phosphodiesterase antibody PDE 1C antibody Phosphodiesterase 1C antibody Phosphodiesterase 1C calmodulin dependent antibody |
Protein information supplied by UniProt
FabGennix PDE1C Antibody has been used in 16 Publications
Applications: Confocal microscopy, Immunodepletion, Immunofluorescence, Immunohistochemistry, and Western blot
Reactivity: Chicken, Human, Mouse, and Rat
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Cesarini, Valeriana, et al. "Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome." Oncotarget (2017).
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PMID: 28099939 Applications: Western Blot Reactivity: Human |
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015).
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PMID: 25578602 Applications: Immunohistochemistry Reactivity: Human |
Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014).
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PMID: 24631654 Applications: Immunohistochemistry, Western Blot Reactivity: Mouse |
Guibinga, Ghiabe-Henri, Fiona Murray, and Nikki Barron. “HPRT-Deficiency Dysregulates cAMP-PKA Signaling and Phosphodiesterase 10A Expression: Mechanistic Insight and Potential Target for Lesch-Nyhan Disease?” Ed. Kjetil Tasken. PLoS ONE 8.5 (2013).
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PMCID: 3653951 Applications: Western Blot Reactivity: Human |
Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011).
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PMID: 21653225 Applications: Immunofluorescence, Western Blot Reactivity: Mouse |
Abusnina, Abdurazzag, et al. "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." Cellular signalling 23.1 (2011).
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PMID: 20807569 Applications: Western Blot Reactivity: Human |
Abusnina, Abdurazzag, et al. "Anti‐proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1." Molecular nutrition & food research 55.11 (2011).
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PMID: 22045655 Applications: Western Blot Reactivity: Human |
Dong, Hongli, et al. "Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells." Biochemical pharmacology 79.3 (2010).
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PMID: 19737543 Applications: Western Blot Reactivity: Human |
Ortiz-Capisano, M. Cecilia et al. “Calcium-Dependent Phosphodiesterase 1C Inhibits Renin Release from Isolated Juxtaglomerular Cells.” American Journal of Physiology - Regulatory, IntegRative and CompaRative Physiology 297.5 (2009).
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PMCID: 2777770 Applications: Confocal microscopy, Immunohistochemistry, Immunofluorescence, Western Blot Reactivity: Mouse |
Tahseldar-Roumieh, Rima et al. “PDEs1-5 Activity and Expression in Tissues of Cirrhotic Rats Reveal a Role for Aortic PDE3 in NO Desensitization.” International Journal of Experimental Pathology 90.6 (2009).
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PMCID: 2803251 Applications: Western Blot Reactivity: Rat |
Deplano, Stefania, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase during ontogenesis of chick retina." Journal of neuroscience research 86.5 (2008).
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PMID: 18041092 Applications: Immunohistochemistry, Western Blot Reactivity: Chicken |
Dunkern, Torsten R., and Armin Hatzelmann. "Characterization Of Inhibitors Of Phosphodiesterase 1C On A Human Cellular System." FEBS Journal 274.18 (2007).
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PMID: 17697115 Applications: Western Blot Reactivity: Human |
Murray, Fiona, et al. "Expression and activity of cAMP phosphodiesterase isoforms in pulmonary artery smooth muscle cells from patients with pulmonary hypertension: role for PDE1." American Journal of Physiology-Lung Cellular and Molecular Physiology 292.1 (2007).
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PMID: 16980375 Applications: Western Blot Reactivity: Human |
Santone, Rocco, et al. "Gene expression and protein localization of calmodulin‐dependent phosphodiesterase in adult Rat retina." Journal of neuroscience research 84.5 (2006).
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PMID: 16881052 Applications: Confocal microscopy, Immunohistochemistry, Western Blot Reactivity: Rat |
Dolci, Susanna, et al. "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases." Biochemical and biophysical research communications 341.3 (2006).
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PMID: 16455054 Applications: Immunodepletion, Immunofluorescence, Western Blot Reactivity: Human |
Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005).
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PMID: 15856425 Applications: Immunofluorescence, Western Blot Reactivity: Mouse |
Publishing research using PD1C-301AP? Please let us know, we can cite the reference in this datasheet.
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