General Information |
|
Product |
KIRREL Peptide |
Description |
Antigenic Blocking Peptide Kin of IRRE-like protein 1 |
Verified Applications |
Immunocompetition, Immunodepletion |
Peptide Description |
Recombinant Neph1 protein. |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
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|
|
Uniprot # |
|
Overview |
Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. |
Molecular Function |
Myosin Binding |
Subcellular Location |
Cell membrane; Single-pass type I membrane protein |
Expression |
Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli. |
Structure |
Interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus). Interacts with NPHS1/nephrin (via the Ig-like domains); this interaction is dependent on KIRREL glycosylation. Homodimer (via the Ig-like domains). Interacts when tyrosine-phosphorylate |
Alternative Nomenclature |
FLJ10845 antibody Kin of IRRE like (Drosophila) antibody Kin of IRRE like antibody Kin of irregular chiasm-like protein 1 antibody Kirrel antibody MGC129542 antibody MGC129543 antibody NEPH 1 antibody Nephrin like protein 1 antibody Nephrin related antibody |
Protein information supplied by UniProt
Fabgennix Nephrin Antibody has been used in 1 Publication |
|
Arif, E. et al. “Motor Protein Myo1c Is a Podocyte Protein That Facilitates the Transport of Slit Diaphragm Protein Neph1 to the Podocyte Membrane .”Molecular and Cellular Biology 31.10 (2011): 2134–2150. PMC3133353 |
Confocal Microscopy, Immunofluorescence, Western Blot; Human, Rat
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Publishing research using NEPH1-101AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
NEPH1-121AP | |||
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NEPH1-121-FITC | |||
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NEPH1-121-BIOTIN | |||
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PC-NEPH1 | |||
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